ADULT-RESPIRATORY-DISTRESS-SYNDROME WITH OR WITHOUT SYSTEMIC-DISEASE ASSOCIATED WITH INFECTIONS DUE TO MYCOPLASMA-FERMENTANS
ADULT-RESPIRATORY-DISTRESS-SYNDROME WITH OR WITHOUT SYSTEMIC-DISEASE ASSOCIATED WITH INFECTIONS DUE TO MYCOPLASMA-FERMENTANS
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DOI：
10.1093/clinids/17.supplement_1.s259
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发表时间：
1993-08-01
影响因子：
11.8
通讯作者：
LEGIER, JF
中科院分区：
文献类型：
--
作者：
LO, SC;WEAR, DJ;LEGIER, JF
一个不寻常的，但典型的临床病理表现，注意到在几组以前健康的，人类免疫缺陷病毒阴性的患者有明显的暴发性感染性疾病，但没有确定的病原体。临床过程的特点是迅速进展和发展成人呼吸窘迫综合征，有或无全身疾病。通过活检或尸检获得的病变组织（除肺外）的组织学变化范围从仅具有极轻微炎症反应的广泛坏死到具有急性炎症局灶性区域的显著淋巴组织细胞浸润。本报告重点介绍了三例患者的肺部变化。肺泡上皮（I型）细胞和II型肺细胞弥漫性受损。间质水肿，间隔增厚。可形成嗜酸性肺泡膜，肺泡腔可充满泡沫状巨噬细胞。免疫组织化学研究确定了患者肺部和肝脏中的发酵支原体感染。支原体样颗粒也可以通过电子显微镜鉴定。有一种以前未被认识的人类暴发性疾病与M。发酵菌感染。
An unusual but typical clinicopathological presentation was noted among several groups of previously healthy, human immunodeficiency virus-negative patients who had an apparent fulminant infectious disease but had no etiologic agent identified. The clinical courses were characterized by rapid progression and development of adult respiratory distress syndrome with or without systemic disease. Histopathological changes in the diseased tissues (other than lung) obtained by biopsy or at autopsy ranged from extensive necrosis with only minimal inflammatory reaction to prominent lymphohistiocytic infiltrate with focal areas of acute inflammation. This report focuses on pulmonary changes in three patients. The alveolar epithelial (type I) cells and type II pneumocytes are diffusely damaged. There is interstitial edema and thickened septa. An eosinophilic alveolar membrane may form, and the alveolar space may fill with foamy macrophages. Immunohistochemical studies identified Mycoplasma fermentans infection in the patients' lungs and liver. Mycoplasma-like particles could also be identified by electron microscopy. There is a previously unrecognized form of fulminant disease in humans that is associated with M. fermentans infections.