Effect of Silk Fibroin Concentration on the Properties of Polyethylene Glycol Dimethacrylates for Digital Light Processing Printing
Effect of Silk Fibroin Concentration on the Properties of Polyethylene Glycol Dimethacrylates for Digital Light Processing Printing
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DOI：
10.1002/adem.202100487
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发表时间：
2021-07-21
影响因子：
3.6
通讯作者：
Narita, Fumio
中科院分区：
文献类型：
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作者：
Egawa, Satoshi;Kurita, Hiroki;Narita, Fumio
由于丝素蛋白（SF）的高生物相容性，尝试使用丝素蛋白（SF）作为再生医学领域中的支架材料，丝素蛋白是由蚕产生的蛋白质。在本文中，SF的浓度变化并与光固化树脂聚乙二醇二甲基丙烯酸酯（PEGDMA）混合以产生生物墨水，并且通过数字光处理（DLP）3D打印来打印水凝胶。然后，为了研究打印的水凝胶的性质，进行扫描电子显微镜（SEM）观察、溶胀行为测量和压缩测试。水凝胶的性质取决于SF的浓度，并且该结果表明，通过控制SF的量，可以产生具有适合于某些组织的性质的支架。
Attempts are made to use silk fibroin (SF), which is a protein produced by the silkworm, as a scaffold material in the field of regenerative medicine due to its high biocompatibility. Herein, the concentration of SF is varied and mixed with the light-curing resin polyethylene glycol dimethacrylate (PEGDMA) to create a bioink, and the hydrogel is printed by digital light processing (DLP) 3D printing. Then, to investigate the properties of the printed hydrogel, scanning electron microscope (SEM) observation, swelling behavior measurement, and compression testing are conducted. The properties of hydrogels depend on the concentration of SF, and this result indicates that it is possible to create a scaffold with properties suitable for some tissue by controlling the amount of SF.