HUMAN P53 IS PHOSPHORYLATED BY P60-CDC2 AND CYCLIN-B-CDC2
HUMAN P53 IS PHOSPHORYLATED BY P60-CDC2 AND CYCLIN-B-CDC2
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DOI：
10.1073/pnas.87.12.4766
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发表时间：
1990-06-01
影响因子：
11.1
通讯作者：
BEACH, D
中科院分区：
文献类型：
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作者：
BISCHOFF, JR;FRIEDMAN, PN;BEACH, D
人类抗癌蛋白P53被证明是CDC2的底物。磷酸化的主要部位是丝氨酸-315。丝氨酸-315被p60-cdc2和细胞周期蛋白B-cdc2酶磷酸化。P53的磷酸化是细胞周期依赖性的。P53的丰度也在细胞周期中振荡。这种蛋白质在刚刚完成分裂的细胞中基本上不存在，但在G1期积累在细胞中。Cdc2的磷酸化可能调节P53的抗增殖活性。
The human anti-oncoprotein p53 is shown to be a substrate of cdc2. The primary site of phosphorylation is serine-315. Serine-315 is phosphorylated by both p60-cdc2 and cyclin B-cdc2 enzymes. The phosphorylation of p53 is cell cycle-dependent. The abundance of p53 also oscillates during the cell cycle. The protein is largely absent from cells that have just completed division but accumulates in cell during G1 phase. Phosphorylation by cdc2 might regulate the antiproliferative activity of p53.