Vasopressin cell groups exhibit strongly divergent responses to copulation and male-male interactions in mice
Vasopressin cell groups exhibit strongly divergent responses to copulation and male-male interactions in mice
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DOI：
10.1016/j.yhbeh.2010.03.021
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发表时间：
2010-08-01
影响因子：
3.5
通讯作者：
Goodson, James L.
中科院分区：
文献类型：
--
作者：
Ho, Jacqueline M.;Murray, John H.;Goodson, James L.
精氨酸后叶加压素及其非哺乳动物同源物精氨酸后叶催产素影响社会行为，从亲缘关系到居民入侵攻击。虽然已经确定了这些行为效应的许多作用位点，但对大脑中特定AVP细胞群的参与知之甚少，并且在啮齿动物中发现的许多AVP细胞群中，社会引发的Fos反应尚未被量化。令人惊讶的是，这包括终纹内侧床核（BSTMP）后部的AVP种群，尽管间接地，但它广泛地牵涉到隶属关系和其他社会行为的各个方面。我们检测了8个下丘脑和3个下丘脑外avp免疫反应（-ir）细胞组对C57BL/6J小鼠交配、非攻击性雄性相互作用和攻击性雄性相互作用的Fos反应。BSTMP细胞表现出与所有其他细胞组不同的反应谱：从与Fos共定位的AVP-ir神经元的5%左右的对照基线开始，在非攻击性雄性相互作用后，共定位显著增加到12%左右，在交配后增加到70%左右。攻击性相互作用并没有增加共定位，超过在非攻击性雄性小鼠中观察到的水平。这些结果表明，小鼠的BSTMP神经元可能选择性地增加AVP-Fos共定位，以响应与依恋相关的刺激，类似于雀类的发现。相比之下，几乎所有其他细胞组都对相互作用的负面方面有反应，要么通过在从属动物中升高AVP-Fos共定位，AVP-Fos共定位与被咬物正相关，和/或AVP-Fos共定位与优势负相关。这些发现极大地扩展了已知的特定脑AVP细胞群对社会行为的贡献。Elsevier Inc.出版。
Arginine vasopressin (AVP) and its nonmammalian homolog arginine vasotocin influence social behaviors ranging from affiliation to resident-intruder aggression. Although numerous sites of action have been established for these behavioral effects, the involvement of specific AVP cell groups in the brain is poorly understood, and socially elicited Fos responses have not been quantified for many of the AVP cell groups found in rodents. Surprisingly, this includes the AVP population in the posterior part of the medial bed nucleus of the stria terminalis (BSTMP), which has been extensively implicated, albeit indirectly, in various aspects of affiliation and other social behaviors. We examined the Fos responses of eight hypothalamic and three extra-hypothalamic AVP-immunoreactive (-ir) cell groups to copulation, nonaggressive male-male interaction, and aggressive male-male interaction in both dominant and subordinate C57BL/6J mice. The BSTMP cells exhibited a response profile that was unlike all other cell groups: from a control baseline of similar to 5% of AVP-ir neurons colocalizing with Fos, colocalization increased significantly to similar to 12% following nonaggressive male-male interaction, and to similar to 70% following copulation. Aggressive interactions did not increase colocalization beyond the level observed in nonaggressive male mice. These results suggest that BSTMP neurons in mice may increase AVP-Fos colocalization selectively in response to affiliation-related stimuli, similar to findings in finches. In contrast, virtually all other cell groups were responsive to negative aspects of interaction, either through elevated AVP-Fos colocalization in subordinate animals, positive correlations of AVP-Fos colocalization with bites received, and/or negative correlations of AVP-Fos colocalization with dominance. These findings greatly expand what is known of the contributions of specific brain AVP cell groups to social behavior. Published by Elsevier Inc.