Identifying frailty in hospitalized older adults with significant coronary artery disease
Identifying frailty in hospitalized older adults with significant coronary artery disease
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DOI：
10.1111/j.1532-5415.2006.00914.x
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发表时间：
2006-11-01
影响因子：
6.3
通讯作者：
Alexander, Karen P.
中科院分区：
文献类型：
--
作者：
Purser, Jama L.;Kuchibhatla, Maragatha N.;Alexander, Karen P.
描述严重冠状动脉疾病（CAD）住院老年人的生理变化，并评估该样本中虚弱的患病率，以确定单项性能指标是否是多维虚弱的良好指标，并估计脆弱和6-月死亡率。观察性队列研究。住院心脏病病房。连续309例70岁及以上住院患者，心脏病学服务（n = 309; 70%男性，84%白色），通过心导管检查确定最小两支血管CAD。两种标准虚弱表型（复合A和复合B），通常的步态速度，握力，椅子站立，心脏病学临床变量和6个月死亡率。复合A的虚弱患病率为27%，复合B为63%。单项测量用于识别虚弱的效用最大的是步态速度（复合A的受试者工作特征曲线c统计量= 0.89，复合B的0.70），其次是椅子站立（c = 0.83，0.66）和握力（c = 0.78，0.57）。调整后，综合评分和单项指标分别与6个月时较高的死亡率相关。慢步态速度（
To characterize physiological variation in hospitalized older adults with severe coronary artery disease (CAD) and evaluate the prevalence of frailty in this sample, to determine whether single-item performance measures are good indicators of multidimensional frailty, and to estimate the association between frailty and 6-month mortality.Observational cohort study.Inpatient hospital cardiology ward.Three hundred nine consecutive inpatients aged 70 and older admitted to a cardiology service (n = 309; 70% male, 84% white) with minimum two-vessel CAD determined using cardiac catheterization.Two standard frailty phenotypes (Composite A and Composite B), usual gait speed, grip strength, chair stands, cardiology clinical variables, and 6-month mortality.Prevalence of frailty was 27% for Composite A versus 63% for Composite B. Utility of single-item measures for identifying frailty was greatest for gait speed (receiver operating characteristic curve c statistic = 0.89 for Composite A, 0.70 for Composite B) followed by chair-stands (c = 0.83, 0.66) and grip strength (c = 0.78, 0.57). After adjustment, composite scores and single-item measures were individually associated with higher mortality at 6 months. Slow gait speed (