NCI, NHLBI/PBMTC first international conference on late effects after pediatric hematopoietic cell transplantation: persistent immune deficiency in pediatric transplant survivors.
NCI, NHLBI/PBMTC first international conference on late effects after pediatric hematopoietic cell transplantation: persistent immune deficiency in pediatric transplant survivors.
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DOI：
10.1016/j.bbmt.2011.11.014
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发表时间：
2012-01
期刊：
影响因子：
--
通讯作者：
Torgerson T
中科院分区：
文献类型：
--
作者：
Bunin N;Small T;Szabolcs P;Baker KS;Pulsipher MA;Torgerson T
免疫重建缺陷是成功的造血细胞移植（HCT）的主要障碍，在儿科人群中具有重要意义。影响免疫恢复的因素有很多，包括干细胞来源和GVHD。完整的免疫恢复评估，包括T和B淋巴细胞评估，先天免疫和对新抗原的反应，可以为感染风险和最佳免疫时间提供见解。脐带血移植的使用越来越多，需要进一步研究早期重建和对生存的影响。免疫接种时间表可能需要根据干细胞来源和免疫重建进行修改，这一点尤其重要，因为许多儿童在入学前未完全免疫，或根本没有免疫。需要在HCT后的儿童中进行进一步的研究，以评估不同干细胞来源对免疫重建、感染风险和免疫反应的影响。
Defective immune reconstitution is a major barrier to successful hematopoietic cell transplantation (HCT), and has important implications in the pediatric population. There are many factors which affect immune recovery, including stem cell source and GVHD. Complete assessment of immune recovery, including T and B lymphocyte evaluation, innate immunity and response to neoantigens, may provide insight as to infection risk and optimal time for immunizations. The increasing use of cord blood grafts requires additional study regarding early reconstitution and impact upon survival. Immunization schedules may require modification based upon stem cell source and immune reconstitution, and this is of particular importance as many children have been incompletely immunized, or not at all, prior to school entry. Additional studies are needed in children post HCT to evaluate the impact of differing stem cell sources upon immune reconstitution, infectious risks and immunization responses.