Cortisol reactivity and emotional memory after psychosocial stress in oral contraceptive users.
Cortisol reactivity and emotional memory after psychosocial stress in oral contraceptive users.
复制标题
口服避孕药使用者心理社会压力后的皮质醇反应和情绪记忆。
DOI：
10.1002/jnr.23904
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发表时间：
2017
影响因子：
4.2
通讯作者：
Maki,PaulineM
中科院分区：
文献类型：
--
作者：
Mordecai,KristenL;Rubin,LeahH;Eatough,Erin;Sundermann,Erin;Drogos,Lauren;Savarese,Antonia;Maki,PaulineM
口服避孕药(OC)使用者通常对心理社会压力表现出迟钝或没有皮质醇反应。虽然大多数OC方案都包括非活动(模拟)和活动的药丸阶段，但研究尚未系统地研究这些药片阶段的皮质醇反应。此外，应激源后高水平的皮质醇会减少对情绪材料的提取，但对OC使用者的压力对记忆的影响知之甚少。我们研究了一种心理社会应激源--特里尔社会压力测试--与对照条件对皮质醇反应性和情绪记忆恢复的影响，这些女性在活动阶段(n= 18)或非活动药片阶段(n= 21)接受了测试。在二次分析中，我们对OC使用者和正常骑行的女性进行了定量比较，发现在活动和非活动的服药阶段，皮质醇反应都明显不足。情绪回忆在活跃和不活跃的服药阶段之间没有区别。与积极词或中性词相比，压力会降低对消极单词的回忆，但皮质醇水平与记忆表现无关。这些发现表明，OC使用者对压力有不同的皮质醇和记忆反应，这在活跃和不活跃的药片阶段是相似的。©2016 Wiley期刊，Inc.
Oral contraceptive (OC) users typically show a blunted or no cortisol response to psychosocial stress. Although most OC regimens include both an inactive (dummy) and active pill phase, studies have not systematically investigated cortisol responses during these pill phases. Further, high levels of cortisol following a stressor diminish retrieval of emotional material, but the effects of stress on memory among OC users are poorly understood. We examined the effects of a psychosocial stressor, the Trier Social Stress Test, vs. a control condition on cortisol responsivity and emotional memory retrieval in women tested either during their active (n= 18) or inactive pill phase (n= 21). In secondary analyses, we quantitatively compared OC users with normally cycling women and showed a significant lack of cortisol response during both active and inactive pill phase. Emotional recall did not differ between active and inactive pill phases. Stress differentially diminished recall of negative words compared with positive or neutral words, but cortisol levels were unrelated to memory performance. These findings indicate that OC users have distinct cortisol and memory responses to stress that are similar between the active and inactive pill phases. © 2016 Wiley Periodicals, Inc.