Less activation in the left dorsolateral prefrontal cortex in the reanalysis of the response to a meal in obese than in lean women and its association with successful weight loss
Less activation in the left dorsolateral prefrontal cortex in the reanalysis of the response to a meal in obese than in lean women and its association with successful weight loss
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DOI：
10.1093/ajcn/86.3.573
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发表时间：
2007-09-01
影响因子：
7.1
通讯作者：
Krakoff, Jonathan
中科院分区：
文献类型：
--
作者：
Le, Duc Son N. T.;Pannacciulli, Nicola;Krakoff, Jonathan
背景资料：我们之前发现肥胖男性在进食时左背外侧前额叶皮层（LDLPFC）的激活程度低于瘦人，这表明这种改变的神经元反应与肥胖的病理生理学之间存在关联。目的：这项研究的目的是在肥胖妇女中扩大这一发现，并调查有严重肥胖史的妇女在这一区域的活动，重量（即，以前肥胖的妇女，有时也被称为postobese妇女）。设计：我们重新分析了先前收集的数据，（在接受液体餐后）与餐前（禁食36小时后）局部脑血流量，神经元活动的标志物，通过使用O-15-水正电子发射断层扫描在10个瘦[26 +/- 6%体脂（1317）]，9名肥胖（39 +/- 3%BF）和8名以前肥胖（28 +/- 4%BF）的右利手女性。数据进行了分析，通过使用2水平，随机效应方差analysis of variance.Results：在LDLPFC的区域脑血流量不同的反应，在3组之间的膳食（P < 0.001，多重比较未校正）。锄后组的比较表明，肥胖妇女在这方面的激活显着低于瘦和以前肥胖的妇女。以前肥胖和瘦women之间没有显着差异被发现。结论：这些结果扩展了我们以前的研究结果，表明肥胖的妇女有较少的激活在LDLPFC在响应一顿饭比瘦或以前肥胖的妇女。后两组在该区域的神经元活动没有显著差异。需要纵向研究来确定神经元活动的这些差异是否随体重变化而变化或预测体重变化。
Background: We previously found that obese men have less activation in the left dorsolateral prefrontal cortex (LDLPFC) in response to a meal than do lean men, which indicates an association between this altered neuronal response and the pathophysiology of obesity.Objectives: The objectives of the study were to extend this finding in obese women and to investigate activity in this region in women with a history of severe obesity who have successfully lost weight (ie, formerly obese women, sometimes called postobese women).Design: We reanalyzed previously collected data to compare postmeal (after receiving a liquid meal) with premeal (after a 36-h fast) regional cerebral blood flow, a marker of neuronal activity, by using O-15-water positron emission tomography in 10 lean [26 +/- 6% body fat (1317)], 9 obese (39 +/- 3%BF) and 8 formerly obese (28 +/- 4%BF) right-handed women. Data were analyzed by using a 2-level, random-effect analysis of variance.Results: The regional cerebral blood flow in the LDLPFC differed in response to the meal across the 3 groups (P < 0.001, uncorrected for multiple comparisons). Post hoe group comparisons showed that obese women had significantly less activation in this area than did lean and formerly obese women. No significant difference between formerly obese and lean women was found.Conclusions: These results extend our previous findings, indicating that obese women have less activation in the LDLPFC in response to a meal than do lean or formerly obese women. Neuronal activity in this region did not differ significantly between the latter 2 groups. Longitudinal studies are needed to determine whether these differences in neuronal activity change with or predict weight change.