Genetic sensitivity to 6-n-propylthiouracil has no influence on dietary patterns, body mass indexes, or plasma lipid profiles of women
Genetic sensitivity to 6-n-propylthiouracil has no influence on dietary patterns, body mass indexes, or plasma lipid profiles of women
复制标题
DOI：
10.1016/j.jada.2007.05.013
复制
发表时间：
2007-08-01
影响因子：
--
通讯作者：
Cockroft, Jennie E.
中科院分区：
文献类型：
--
作者：
Drewnowski, Adam;Henderson, Susan A.;Cockroft, Jennie E.
背景6-丙基硫氧嘧啶(PROP)对苦味的遗传敏感性已被报道决定了人们对苦味、甜味和含脂肪食物的偏好，影响饮食习惯，影响体重，并改变慢性病风险。目的在成年女性的临床样本中检查PROP反应、食物选择、饮食摄入量和血浆化学之间的关系。食物偏好基于171项清单。食物和营养素的摄入量使用食物频率问卷进行评估。测量身高和体重，并获得血浆胆固醇和甘油三酯水平。结果高道具反应与报告的对甜食或高脂肪食物的偏好无关。道具反应与报告的食物使用频率或饮食中的常量营养素组成无关。在回归模型中，在调整协变量后，道具反应性对膳食脂肪百分比、体重指数或血浆胆固醇没有影响。结论在本研究中，道具反应性与饮食中糖和脂肪含量较低、较有利的血脂水平或较低的体重指数无关。这项研究没有提供证据表明基因道具品尝者的身份对健康结果有可衡量的影响。这些研究结果并不支持道具品尝师筛查的临床效用。
Background Genetic sensitivity to the bitter taste of 6-n-propylthiouracil (PROP) has been reported to determine preferences for bitter, sweet, and fat-containing foods, affect dietary habits, influence body weight, and modify chronic disease risk.Objective To examine associations between PROP responsiveness, food choices, dietary intakes, and plasma chemistries in a clinical sample of adult women.Subjects/design This nested case-control study was based on female breast cancer patients (n = 179) and cancer-free controls (n = 179).Main outcome measures Taste responsiveness measure was based on a 25:50:25 split of summed bitterness ratings of five PROP solutions. Food preferences were based on a 171-item checklist. Food and nutrient intakes were assessed using a food frequency questionnaire. Heights and weights were measured and plasma cholesterol and triglyceride levels were obtained.Results High PROP response was unrelated to reported preferences for sweet or high-fat foods. PROP responsiveness was unrelated to the reported frequency of food use, or to macronutrient composition of the diet. In regression models, PROP responsiveness had no influence on percent of dietary fat, body mass index, or plasma cholesterol, after adjusting for covariates.Conclusions In this study PROP responsiveness was not associated with diets lower in sugar and fat, more favorable plasma lipid profiles, or with lower body mass indexes. The study provided no evidence to suggest that genetic PROP taster status had a measurable influence on health outcomes. The clinical utility of PROP taster screening is not supported by these study results.