Dendritic cell apoptosis in the maintenance of immune tolerance
Dendritic cell apoptosis in the maintenance of immune tolerance
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DOI：
10.1126/science.1122545
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发表时间：
2006-02-24
期刊：
影响因子：
56.9
通讯作者：
Wang, J
中科院分区：
文献类型：
--
作者：
Chen, M;Wang, YH;Wang, J
免疫系统中的细胞凋亡对于维持自身耐受性和防止自身免疫至关重要。然而，抑制淋巴细胞的凋亡并不足以打破自身耐受性，这表明其他类型的细胞也参与其中。我们通过在树突状细胞(DC-p35)中产生表达杆状病毒caspase抑制物p35的转基因小鼠，研究了树突状细胞(DC)中的凋亡是否有助于调节自身耐受。DC-p35小鼠表现出缺陷的DC细胞凋亡，导致DC细胞积聚，进而导致慢性淋巴细胞激活和全身自身免疫表现。观察到DC凋亡缺陷可以独立地导致自身免疫，这与这些细胞维持免疫自我耐受的中心机制是一致的。
Apoptosis in the immune system is critical for maintaining self-tolerance and preventing autoimmunity. Nevertheless, inhibiting apoptosis in lymphocytes is not alone sufficient to break self-tolerance, suggesting the involvement of other cell types. We investigated whether apoptosis in dendritic cells (DCs) helps regulate self-tolerance by generating transgenic mice expressing the baculoviral caspase inhibitor, p35, in DCs (DC-p35). DC-p35 mice displayed defective DC apoptosis, resulting in their accumulation and, in turn, chronic lymphocyte activation and systemic autoimmune manifestations. The observation that a defect in DC apoptosis can independently lead to autoimmunity is consistent with a central rote for these cells in maintaining immune self-tolerance.