Topographic Analysis of the Choriocapillaris in Intermediate Age-related Macular Degeneration
Topographic Analysis of the Choriocapillaris in Intermediate Age-related Macular Degeneration
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DOI：
10.1016/j.ajo.2018.08.014
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发表时间：
2018-12-01
影响因子：
4.2
通讯作者：
Sadda, Srinivas R.
中科院分区：
文献类型：
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作者：
Borrelli, Enrico;Shi, Yue;Sadda, Srinivas R.
目的：利用扫源光学相干断层扫描血管造影（SS-OCTA）成像，定量分析中度年龄相关性黄斑变性（iAMD）患者的绒毛膜毛细血管（CC）的区域差异。设计：横断面研究。方法：使用SS-OCTA系统（PLEX Elite 9000, Carl Zeiss Meditec Inc, Dublin, California， USA）对受试者进行成像。首先利用同一块板的结构信息对CC人脸图像的信号衰减进行补偿。随后，对每只眼睛，对2个不同OCTA体积扫描集生成的2张补偿CC人脸图像进行配准和平均。然后将平均CC图像导出到Image)并进行二值化以进行后续定量分析。除了对全眼平均CC人脸图像进行分析外，还对3个不同的区域进行了定量分析：(1)毒瘤区，(2)毒瘤边界周围150 μ m宽的环，(3)无毒瘤区。结果：30只眼（30例患者）和30只健康眼（30例对照）被纳入研究。与对照组相比，iAMD眼的信号空洞数量较少（中位数和四分位数范围[IQR]: 2561和2343-2746比2734和2558-2834，P = 0.013），信号空洞平均大小较大(中位数，IQR: 581.9亩m(2), 466.1-726.9亩m(2)比503.8亩m(2), 429.1-576.8亩m(2)；P = 0.027)，总信号空洞面积更大（中位数，IQR: 26.0%, 22.1%-29.6% vs 23.8%, 21.2%-26.4%; P = 0.038）。在多元回归分析中，iAMD的存在与任何CC变量均无显著相关。相比之下，枯枝区面积与CC的改变显著相关。在iAMD组的评价中，与未患病区相比，患病区下方和患病区周围150 μ m宽的环形区域的总信号空洞面积均有所增加（P = 0.005和P = 0.045）。结论：中度AMD眼表现出CC血流损害加重，其共定位于眼球下方和周围的CC区域。[J]中华眼科杂志，2018;36:344 - 344。(C) 2018爱思唯尔公司版权所有。
PURPOSE: To quantitate regional differences in the choriocapillaris (CC) of patients with intermediate age-related macular degeneration (iAMD), using swept source optical coherence tomography angiography (SS-OCTA) imaging.DESIGN: Cross-sectional study.METHODS: Subjects were imaged with the SS-OCTA system (PLEX Elite 9000, Carl Zeiss Meditec Inc, Dublin, California, USA). The CC en face images were first compensated for the signal attenuation caused by drusen by using the structural information from the same slab. Subsequently, for each eye, 2 compensated CC en face images generated from 2 different OCTA volume scan sets were registered and averaged. The averaged CC images were then exported to Image) and binarized for subsequent quantitative analysis. In addition to the analysis of the whole averaged CC en face image in iAMD eyes, quantitative analysis was also performed in 3 different regions: (1) drusen region, (2) 150-mu m-wide ring around the drusen border, and (3) drusen-free region.RESULTS: Thirty eyes (30 patients) with iAMD and 30 healthy eyes from 30 controls were enrolled. Compared with controls, iAMD eyes displayed a lower number of signal voids (median and interquartile range [IQR]: 2561 and 2343-2746 vs 2734 and 2558-2834; P = .013), a greater signal void average size (median, IQR: 581.9 mu m(2), 466.1-726.9 mu m(2) vs 503.8 mu m(2), 429.1-576.8 mu m(2); P = .027), and a greater total signal void area (median, IQR: 26.0%, 22.1%-29.6% vs 23.8%, 21.2%-26.4%; P = .038). In multiple regression analysis, the presence of iAMD was not significantly associated with any of the CC variables. By contrast, the drusen region area was significantly associated with CC alterations. In the evaluation of the iAMD group, both the area underneath drusen and the 150-mu m-wide ring region around drusen were characterized by an increased total signal void area (P = .005 and P = .045, respectively) vs the drusen-free region.CONCLUSIONS: Intermediate AMD eyes demonstrated increased CC flow impairment, which co-localizes to the area of CC beneath and immediately surrounding drusen. (Am J Ophthalmol 2018;196:34-43. (C) 2018 Elsevier Inc. All rights reserved.