The relationship of FOXP3 expression and clinicopathological characteristics in adult T-cell leukemia/lymphoma
The relationship of FOXP3 expression and clinicopathological characteristics in adult T-cell leukemia/lymphoma
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DOI：
10.1038/modpathol.2008.25
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发表时间：
2008-05-01
期刊：
影响因子：
7.5
通讯作者：
Ohshima, Koichi
中科院分区：
文献类型：
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作者：
Karube, Kennosuke;Aoki, Ryosuke;Ohshima, Koichi
成人T细胞白血病/淋巴瘤是一种与调节性T细胞相关的侵袭性恶性疾病，如最近的一些报道所讨论的。我们分析了FOXP 3（调节性T细胞的关键分子）在成人T细胞白血病/淋巴瘤中的表达及其与临床病理特征的关系。在169例成人T细胞白血病/淋巴瘤病例中，60例（36%）显示FOXP 3在淋巴瘤细胞中表达。形态学上，22例为间变性大细胞型，147例为多形性细胞型。仅1例（5%）间变性大细胞变异病例和59/147例（40%）多形性细胞变异病例表达FOXP 3。在FOXP 3（+）病例中发现EB病毒感染细胞的频率（23/60; 38%）显著高于FOXP 3（-）病例（12/109; 11%）（P
Adult T-cell leukemia/lymphoma is an aggressive malignant disease associated with regulatory T cells as discussed in some recent reports. We analyzed the expression of FOXP3, a key molecule of regulatory T cells, in adult T-cell leukemia/lymphoma and its association with clinicopathological features. Of 169 adult T-cell leukemia/lymphoma cases examined, 60 (36%) showed FOXP3 expression in lymphoma cells. Morphologically, 22 cases were classified as anaplastic large cell variant and 147 as pleomorphic cell variant. Only 1 (5%) of the anaplastic large cell variant cases and 59/147 (40%) of the pleomorphic cell variant cases expressed FOXP3. Epstein-Barr virus-infected cells were significantly more frequently found in FOXP3(+) cases (23/60; 38%) than in FOXP3(-) cases (12/109; 11%) (P