A prospective study of soluble receptor for advanced glycation end-products and colorectal cancer risk in postmenopausal women
A prospective study of soluble receptor for advanced glycation end-products and colorectal cancer risk in postmenopausal women
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DOI：
10.1016/j.canep.2016.04.004
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发表时间：
2016-06-01
影响因子：
2.6
通讯作者：
Jiaoa, Li
中科院分区：
文献类型：
--
作者：
Chen, Liang;Duan, Zhigang;Jiaoa, Li
目的：脂肪细胞和免疫细胞上表达的晚期糖基化终产物受体（RAGE）可以与配体Ne-（羧甲基）-赖氨酸（CML）结合，并引发脂肪因子调节失调和慢性炎症。可溶性淀粉（sodium）减轻淀粉的有害影响。我们研究了循环水平的CML-AGE和slippery和结直肠癌（CRC）之间的关联：在妇女健康倡议研究的病例队列研究，血液中的CML-AGE和slippery水平进行了测定，使用ELISA。我们使用多变量考克斯回归模型来估计风险比（HR）和95%置信区间（CI）的事件CRC的四分位数（Q）的生物标志物levels.Results：平均随访7.8年的444例和805 subcohort成员。亚队列中CML-AGE、sCRP与BMI呈负相关（P < 0.0001）。CML-AGE和sCRP水平与结直肠癌无关。在BMI特异性分析中，观察到了结肠癌和结肠癌之间的关联。在BMI >= 25 kg/m2的女性中，与BMI水平最低的女性相比，BMI水平最高的女性患CRC的风险显著降低（HRQ 4 vs Q1：0.39; 95%CI：0.17-0.91）。在BMI < 25 kg/m2的妇女中没有观察到这种负相关（P值为交互作用= 0.01）。结论：在绝经后妇女中，肥胖相关的结直肠癌可能与β-肾上腺素通路有关。(C)2016爱思唯尔有限公司版权所有。
Objectives: Receptor for advanced glycation end products (RAGE) expressed on adipocytes and immune cells can bind to ligand Ne-(carboxymethyl)-lysine (CML) and trigger dysregulation of adipokines and chronic inflammation. Soluble RAGE (sRAGE) mitigates the detrimental effect of RAGE. We examined the associations between circulating levels of CML-AGE and sRAGE and colorectal cancer (CRC).Methods: In a case-cohort study of the Women's Health Initiative Study, blood levels of CML-AGE and sRAGE were measured using ELISA. We used multivariable Cox regression model to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of incident CRC in relation to quartiles (Q) of biomarker levels.Results: Average follow-up was 7.8 years for 444 cases and 805 subcohort members. In the subcohort, CML-AGE and sRAGE were inversely correlated with BMI (P values < 0.0001). Levels of CML-AGE and sRAGE were not associated with CRC. In BMI-specific analysis, the association between sRAGE and CRC was observed. Among women with BMI >= 25 kg/m(2), those with highest levels of sRAGE had significantly lower risk for CRC as compared to women with lowest levels of sRAGE (HRQ4 versus Q1: 0.39; 95% CI: 0.17-0.91). This inverse association was not observed among women with BMI < 25 kg/m(2) (P value for interaction = 0.01).Conclusions: Among postmenopausal women, the RAGE pathway may be involved in obesity-related CRC. (C) 2016 Elsevier Ltd. All rights reserved.