Spirulina ameliorates aspirin-induced gastric ulcer in albino mice by alleviating oxidative stress and inflammation
Spirulina ameliorates aspirin-induced gastric ulcer in albino mice by alleviating oxidative stress and inflammation
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DOI：
10.1016/j.biopha.2018.10.118
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发表时间：
2019-01-01
影响因子：
7.5
通讯作者：
Abd El-Ghffar, Eman A.
中科院分区：
文献类型：
--
作者：
Mahmoud, Yomna, I;Abd El-Ghffar, Eman A.
阿司匹林是一种常用的非类固醇消炎药，但长期使用会损伤胃粘膜。本研究旨在评价螺旋藻对阿司匹林所致小鼠胃溃疡的改善作用。用阿司匹林(500 mg/kg体重)灌胃诱导大鼠胃溃疡。螺旋藻(250和500 mg/kgbw)诱导胃溃疡后3d灌胃给药。螺旋藻通过改善胃组织的大体形态、组织学和粘膜层，增加内源性酶和非酶类抗氧化剂(还原型谷胱甘肽、谷胱甘肽过氧化物酶、谷胱甘肽还原酶、超氧化物歧化酶和过氧化氢酶)和细胞保护标记物(COX-1)，以及通过减轻组织中脂质过氧化标记物(丙二醛)和炎症介质(TNF-α、COX-2和NO)的水平来改善阿司匹林诱导的胃溃疡。综上所述，螺旋藻通过减轻氧化应激和炎症，对阿司匹林引起的胃损伤具有治疗潜力。
Aspirin is a commonly prescribed non steroidal anti-inflammatory drug, but its prolonged use injures the gastric mucosa. The present study was carried out to evaluate the ameliorative effect of spirulina against aspirin-induced gastric ulcer in albino mice. Gastric ulcer was induced by oral administration of aspirin (500 mg/kg bw). Spirulina (250 and 500 mg/kg bw) was given orally for 3 days after the induction of gastric ulcer. Spirulina ameliorated aspirin-induced gastric ulcer by improving the gross morphology, histology and mucous layer of gastric tissue, augmenting the endogenous enzymatic and non-enzymatic antioxidants (reduced glutathione, glutathione peroxidase, glutathione reductase, superoxide dismutase and catalase) and the cytoprotective marker (COX-1), and by alleviating tissue levels of the lipid peroxidation marker (malondialdehyde) and inflammatory mediators (TNF-alpha, COX-2 and NO). In conclusion, spirulina has a therapeutic potential in aspirin-induced gastric injury by alleviating oxidative stress and inflammation.