RISK-FACTORS FOR HEART-FAILURE IN THE GENERAL-POPULATION - THE STUDY OF MEN BORN IN 1913
RISK-FACTORS FOR HEART-FAILURE IN THE GENERAL-POPULATION - THE STUDY OF MEN BORN IN 1913
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DOI：
10.1093/oxfordjournals.eurheartj.a059542
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发表时间：
1989-07-01
影响因子：
39.3
通讯作者：
WILHELMSEN, L
中科院分区：
文献类型：
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作者：
ERIKSSON, H;SVARDSUDD, K;WILHELMSEN, L
1963年，从瑞典哥德堡的人口登记中抽取了973名男性样本，他们都是50岁。这些人已经被跟踪了17年，反复检查一些可能与心血管疾病相关的变量。最近的一次检查是在67岁的时候，重点是充血性心力衰竭(CHF)。显性心力衰竭的发病率从1.5到10.2例(1000人)-1岁-1不等，这取决于所研究的年龄组。在50-67岁年龄组中，明显心力衰竭的发生率为5.5(1000)-1岁。确定了大量与获得CHF风险相关的因素。多因素回归分析显示，高血压和吸烟是主要的独立危险因素。体重、心脏体积、T波异常、心率变异性、最大呼气流速、心理压力和FY抗原(一种遗传标记？)也是独立的危险因素。讨论了可能的预防策略。
In 1963 a sample of 973 men, all 50 years old, was drawn from the population register for Gothenburg, Sweden. These men have been followed up for 17 years with repeated examinations regarding a number of variables possible related to cardiovascular disease. The latest examination, at the age of 67 years, focused on congestive heart failure (CHF). The incidence rate of manifest CHF varied from 1.5 to 10.2 cases (1000 population)-1 yr-1, depending on which age group was being studied. For the age group 50-67 years the incidence of manifest CHF was 5.5 (1000)-1 yr-1. A large number of factors associated with the risk of acquiring CHF were identified. In multivariate regression analyses, hypertension and smoking were the major independent risk factors. Body weight, heart volume, T-wave abnormalities, heart rate variability, peak expiratory flow rate, psychological stress and Fy-antigen (a genetic marker?) were also independent risk factors. Possible strategies for prevention are discussed.