Improved allocation of costs through analysis of variation in data: planning of laboratory studies.
Improved allocation of costs through analysis of variation in data: planning of laboratory studies.
复制标题
通过分析数据变化改进成本分配：实验室研究规划。
DOI：
10.1016/s0009-8981(01)00630-1
复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Asztalos,BF
中科院分区：
文献类型：
--
作者：
Foster,TA;Asztalos,BF
BackgroundWhen developing a new laboratory test for study of human diseases, it is important to identify and control internal and external sources of variation that affect test results. It is also imperative that the precision of the test not only meets pre-established requirements and not exceed allowable total error, but also that these objectives are reached without undue expenditure of either time or financial resources.MethodsThis study applies statistical principles in designing a cost-effective experimental approach for determining the analytical precision of a new test. This approach applies the statistical concept of variance components to the problem of balancing a pre-established level of analytical precision against expenses incurred in achieving this precision.ResultsWe demonstrated (1) estimation of variance components, (2) use of these estimates for improving allocation of costs within the experiment, and (3) use of these estimates for determining the optimal number of replicate measurements.ConclusionsAlthough elimination of all sources of variation that can affect laboratory test results is unlikely, the application of analysis of variance (ANOVA) statistical techniques can lead to a cost-effective allocation of resources for estimating the precision of a laboratory test.
