Patterns of staining for neurone specific enolase in benign and malignant melanocytic lesions of the skin.
Patterns of staining for neurone specific enolase in benign and malignant melanocytic lesions of the skin.
复制标题
皮肤良性和恶性黑素细胞病变中神经元特异性烯醇化酶的染色模式。
作者：
Dhillon Ap;J. Rode
神经元特异性烯醇化酶(NSE)是黑色素瘤的有用标记物，不依赖于黑素生成的标准。已经对一系列良性和恶性黑素细胞皮肤病变进行了研究，以评估NSE染色的诊断潜力。本文报告了47例皮损中NSE的存在和分布的详细特征。其中交界性黑色素瘤3例，混合性黑色素瘤7例，皮内型黑色素瘤15例，斯皮兹痣8例，浅表型黑色素瘤6例，恶性雀斑样痣2例，结节性黑色素瘤6例。从良性到恶性，NSE的染色逐渐增加。斯皮茨痣很容易与黑色素瘤相鉴别。这种染色的优点是可以同时显示这些病变的神经支配。我们的结论是，NSE对黑素细胞皮肤肿瘤的诊断和评估是有用的辅助手段，并可能在阐明这些神秘病变的性质方面有价值。
Neurone specific enolase (NSE) is a useful marker for melanoma independent of the criterion of melanogenesis. A range of benign and malignant melanocytic skin lesions has been studied to assess the diagnostic potential of staining for NSE. The detailed features of the presence and distribution of NSE in 47 skin lesions are presented. These include 3 junctional, 7 compound, 15 intradermal and 8 SPitz naevi; 6 superficial type, 2 lentigo maligna and 6 nodular melanomata. A progressive increase of staining for NSE from benign to malignant is seen. Spitz naevi could easily be differentiated from melanoma. An advantage of this stain is the simultaneous demonstration of the innervation of these lesions. We conclude that NSE is a useful aid to the diagnosis and assessment of melanocytic skin tumours and may prove of value in clarifying the nature of these enigmatic lesions.