Garlic and Heart Disease
Garlic and Heart Disease
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DOI：
10.3945/jn.114.202333
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发表时间：
2016-02-01
影响因子：
4.2
通讯作者：
Budoff, Matthew J.
中科院分区：
文献类型：
--
作者：
Varshney, Ravi;Budoff, Matthew J.
背景：基于动物和人体研究，已经发表了数千项研究来评估大蒜的效果和安全性。目的：我们回顾了大蒜补充剂对高血压、高胆固醇血症、C-反应蛋白（CRP）、脉搏波速度（PWV）和冠状动脉钙（CAC）的影响的现有文献，以及有关副作用的现有数据。我们使用医学主题词检索了PubMed中截至2013年5月30日的所有人体研究，并评估了相关综述文章和原始研究。仅纳入双盲、随机、对照试验和双盲、随机、对照试验的荟萃分析。文章的审查和数据提取进行了2个独立的作者，与任何分歧解决consensus.Results：大蒜补充降低血压7-16毫米汞柱（收缩压）和5-9毫米汞柱（舒张压）（4 Meta分析和2个原始研究）。总胆固醇降低7.4-29.8 mg/dL（0项荟萃分析）。- 在使用老化大蒜提取物（AGE）的研究中显示出最一致的益处。一些使用AGE的小型研究也显示出对CAC、CRP和PWV的有利影响。虽然大蒜一般是安全的，罕见的不良反应已被记录有限的因果关系established.Conclusion：我们得出结论，大蒜补充剂具有潜在的心血管保护的基础上减少危险因素（高血压和总胆固醇）和动脉粥样硬化的替代标志物（CRP，PWV，结束CAC）。需要进行更大规模的研究来进一步评估这些影响。
Backkground: Thousands of studies have been published based on animal and human studies evaluating garlic's effects and safety.Objective: We reviewed the available literature investigating the effects of garlic supplements on hypertension, hypercholesterolemia, C-reactive protein (CRP), pulse wave velocity (PWV), and coronary artery calcium (CAC), as well as available data on side effects.Methods: We searched PubMed for all human studies using medical subject heading words through 30 May 2013 and assessed relevant review articles and original studies. Only double-blind, randomized, Controlled trials and meta-analyses of double-blind, randomized, controlled trials were included. The review of articles and data extraction were performed by 2 independent authors, with any disagreements resolved by consensus.Results: Garlic supplementation reduced blood pressure by 7-16 mm Hg (systolic) and 5-9 mm Hg (diastolic) (4 meta analyses and 2 original studies). It reduced total cholesterol by 7.4-29.8 mg/dL (0 meta-analyses). -the most consistent benefits were shown in studies that used aged garlic extract (AGE). A few small studies that used AGE also showed favorable effects on CAC, CRP, and PWV. Although garlic is generally safe, rare adverse reactions have been documented with limited causality established.Conclusion: We conclude that garlic supplementation has the potential for cardiovascular protection based on risk factor reduction (hypertension and total cholesterol) and surrogate markers (CRP, PWV, end CAC) of atherosclerosis. Larger studies are warranted to evaluate these effects further.