Associations between white blood cell count and risk for cerebrovascular disease mortality: NHANES II mortality study, 1976-1992
Associations between white blood cell count and risk for cerebrovascular disease mortality: NHANES II mortality study, 1976-1992
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DOI：
10.1016/j.annepidem.2003.11.002
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发表时间：
2004-07-01
影响因子：
5.6
通讯作者：
Mokdad, AH
中科院分区：
文献类型：
--
作者：
Brown, DW;Ford, ES;Mokdad, AH
目的：检验白细胞计数(WBC)升高与脑血管疾病(CeVD)死亡率之间的关系，该研究与吸烟和性别无关。方法：我们对NHANES 11死亡率研究(1976-1992)中年龄在30-75岁的8459名成年人(3982名男性；4477名女性)的数据进行了Cox回归分析，以评估WBC四分位数中死于CeVD的相对风险。结果：在17年的随访中，共有192名(93名男性；99名女性)死于脑血管疾病。与WBC(Cells/mm(3))和lt；5700相比，WBC和GT；8200的成年人在调整了吸烟和其他心血管疾病危险因素后，CEVD死亡的风险增加(相对风险[RR]，2.1；95%可信区间[CI]，1.2-3.7)。在从不吸烟的人中也观察到了类似的结果(1111，2.0；95%氯，1.0-3.8)。WBC>；8200携带者与WBC<；5700携带者相比，CEVD死亡的调整后相对危险度在男性为1.5(95%CI，0.7-3.5)，在女性为2.7(95%CI，1.45.0)。结论：即使考虑吸烟和其他心血管疾病危险因素的影响，WBC升高仍可预测CeVD死亡率。(C)2004 Elsevier Inc.保留所有权利。
PURPOSE: To examine associations between elevated white blood cell count (WBC) and cerebrovascular disease (CeVD) mortality independent of cigarette smoking and by gender.METHODS: We used Cox regression analyses of data from 8459 adults (3982 men; 4477 women) aged 30 to 75 years in the NHANES 11 Mortality Study (1976-1992) to estimate the relative risk of death from CeVD across quartiles of WBC.RESULTS: During 17 years of follow-up, there were 192 deaths from CeVD (93 men; 99 women). Compared with those with WBC (cells/mm(3)) < 5700, adults with WBC > 8200 were at increased risk of CeVD mortality (relative risk [RR], 2.1; 95% confidence interval [CI], 1.2-3.7) after adjustment for smoking and other cardiovascular disease risk factors. Similar results were observed among never smokers (1111, 2.0; 95% Cl, 1.0-3.8). The adjusted relative risk of CeVD mortality comparing those with WBC > 8200 to those with WBC < 5700 was 1.5 (95% Cl, 0.7-3.5) among men and 2.7 (95% Cl, 1.45.0) among women.CONCLUSIONS: Elevated WBC may predict CeVD mortality even after considering the effects of smoking and other cardiovascular disease risk factors. (C) 2004 Elsevier Inc. All rights reserved.