Ambulatory monitoring of freezing of gait in Parkinson's disease
Ambulatory monitoring of freezing of gait in Parkinson's disease
复制标题
DOI：
10.1016/j.jneumeth.2007.08.023
复制
发表时间：
2008-01-30
影响因子：
3
通讯作者：
Ondo, William G.
中科院分区：
文献类型：
--
作者：
Moore, Steven T.;MacDougall, Hamish G.;Ondo, William G.
步态冻结（FOG）在晚期帕金森病（PD）中很常见，对治疗有抵抗力，并对生活质量产生负面影响。在这项研究中，在11例PD患者中验证了动态FOG监测仪。左小腿的垂直线性加速度是使用安装在脚踝上的传感器阵列以100 Hz的速率将数据无线传输到袖珍PC来获取的。功率分析显示，在FOG期间，在3-8 Hz频带中的腿部运动的高频分量在自主站立期间不明显，并且在FOG之前步行（转弯或障碍物）期间，该“冻结”频带中的功率高于（p = 0.00003）FOG之前休息（步态启动）。冻结指数（FI）定义为“冻结”带中的功率除以“运动”带中的功率（0.5-3 Hz），并选择阈值，使得高于此限值的FI值被指定为FOG。全局阈值检测到78%的FOG事件和20%的立架事件被错误地标记为FOG。冻结阈值的单独校准将设备的准确性和灵敏度提高到89%，用于检测FOG，假阳性率为10%。动态监测可显著改善FOG的临床管理。(c)2007 Elsevier B. V.保留所有权利。
Freezing of gait (FOG) is common in advanced Parkinson's disease (PD), is resistant to treatment and negatively impacts quality of life. In this study an ambulatory FOG monitor was validated in 11 PD patients. The vertical linear acceleration of the left shank was acquired using an ankle-mounted sensor array that transmitted data wirelessly to a pocket PC at a rate of 100 Hz. Power analysis showed high-frequency components of leg movement during FOG in the 3-8 Hz band that were not apparent during volitional standing, and power in this 'freeze' band was higher (p = 0.00003) during FOG preceded by walking (turning or obstacles) than FOG preceded by rest (gait initiation). A freeze index (FI) was defined as the power in the 'freeze' band divided by the power in the 'locomotor' band (0.5-3 Hz) and a threshold chosen such that FI values above this limit were designated as FOG. A global threshold detected 78% of FOG events and 20% of stand events were incorrectly labeled as FOG. Individual calibration of the freeze threshold improved accuracy and sensitivity of the device to 89% for detection of FOG with 10% false positives. Ambulatory monitoring may significantly improve clinical management of FOG. (c) 2007 Elsevier B.V. All rights reserved.