Growth and mechanobiology of the tendon-bone enthesis.
Growth and mechanobiology of the tendon-bone enthesis.
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DOI：
10.1016/j.semcdb.2021.07.015
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发表时间：
2022-03
影响因子：
7.3
通讯作者：
Killian ML
中科院分区：
文献类型：
--
作者：
Killian ML
肌腱是将骨骼肌产生的主动力和被动力传递到骨骼的索状结缔组织。在成熟骨骼中，腱-骨附着点是位于两种机械上不同的组织之间的过渡组织的界面区：柔顺的纤维腱与刚性的致密矿化骨。在这篇综述中，我们专注于新兴领域的附着点发展有关的结构，功能和机械生物学，以及突出建立和新兴的信号通路和生理过程，影响这一重要的过渡组织的形成和适应。
Tendons are cable-like connective tissues that transfer both active and passive forces generated by skeletal muscle to bone. In the mature skeleton, the tendon-bone enthesis is an interfacial zone of transitional tissue located between two mechanically dissimilar tissues: compliant, fibrous tendon to rigid, dense mineralized bone. In this review, we focus on emerging areas in enthesis development related to its structure, function, and mechanobiology, as well as highlight established and emerging signaling pathways and physiological processes that influence the formation and adaptation of this important transitional tissue.