Viral dynamics in asymptomatic patients with COVID-19
Viral dynamics in asymptomatic patients with COVID-19
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DOI：
10.1016/j.ijid.2020.05.030
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发表时间：
2020-07-01
影响因子：
8.4
通讯作者：
Wu, Xianbo
中科院分区：
文献类型：
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作者：
Zhou, Rui;Li, Furong;Wu, Xianbo
关于2019冠状病毒病（COVID-19）无症状患者（APs）的病毒载量、病毒脱落模式和潜在传染性的数据有限。本研究纳入了31名病毒学确诊为COVID-19但入院时无症状的成年患者。31例患者中22例入院后出现症状，定义为潜伏期无症状患者（api）；其余9例患者在住院期间无症状，定义为无症状患者（APs）。ap的中位周期阈值（Ct）（39.0，四分位间距（IQR） 37.5 ~ 39.5）显著高于api (34.5, IQR 32.2 ~ 37.0)，表明ap的病毒载量较低。然而，病毒脱落的持续时间在两组中保持相似（7天，IQR 5-14天与8天，IQR 5-16天）。研究结果表明，虽然感染新冠病毒的ap病毒载量较低，但仍有一定的病毒脱落期，这表明在无症状期存在传播的可能性。有必要通过病毒核酸检测对这些无症状病例进行进一步的纵向监测。(C) 2020作者。由爱思唯尔有限公司代表国际传染病学会出版。
Data are limited on the viral load, viral shedding patterns, and potential infectivity of asymptomatic patients (APs) with coronavirus disease 2019 (COVID-19). This study included 31 adult patients who were virologically confirmed to have COVID-19 but were asymptomatic on admission. Among these 31 patients, 22 presented symptoms after admission and were defined as asymptomatic patients in the incubation period (APIs); the other nine patients remained asymptomatic during hospitalization and were defined as asymptomatic patients (APs). The median cycle threshold (Ct) value of APs (39.0, interquartile range (IQR) 37.5-39.5) was significantly higher than that of APIs (34.5, IQR 32.2-37.0), indicating a lower viral load in APs. However, the duration of viral shedding remained similar in the two groups (7 days, IQR 5-14 days vs. 8 days, IQR 5-16 days). The study findings demonstrated that although APs with COVID-19 have a lower viral load, they still have certain period of viral shedding, which suggests the possibility of transmission during their asymptomatic period. Further longitudinal surveillance of these asymptomatic cases via virus nucleic acid testing are warranted. (C) 2020 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.