Acute intermittent hypoxia enhances corticospinal synaptic plasticity in humans
Acute intermittent hypoxia enhances corticospinal synaptic plasticity in humans
复制标题
DOI：
10.7554/elife.34304
复制
发表时间：
2018-04-24
期刊：
影响因子：
7.7
通讯作者：
Perez, Monica A.
中科院分区：
文献类型：
--
作者：
Christiansen, Lasse;Urbin, M. A.;Perez, Monica A.
急性间歇缺氧（AIH）可增强中枢神经系统损伤患者的自主运动输出。导致这些有益作用的神经机制尚不清楚。我们通过评估皮质脊髓轴突皮层和皮层下刺激引发的运动诱发电位（MEPs）以及AIH或假性AIH前后30分钟手指肌肉皮质内回路的活动来检测皮质脊髓功能。我们发现，AIH后75分钟，皮质和皮质下激发的MEPs振幅增加，但假性AIH后没有增加，而皮质内活动保持不变。为了进一步研究这些皮层下效应，我们评估了针对脊髓突触的spike-timing dependent plasticity （STDP）和脊髓运动神经元的兴奋性。值得注意的是，AIH增加了STDP的结果，而脊髓运动神经元的兴奋性保持不变。我们的结果提供了AIH改变人类皮质脊髓功能的第一个证据，可能是通过改变皮质脊髓-运动神经元突触传递。AIH可能代表了一种新的无创方法来诱导人类脊柱可塑性。
Acute intermittent hypoxia (AIH) enhances voluntary motor output in humans with central nervous system damage. The neural mechanisms contributing to these beneficial effects are unknown. We examined corticospinal function by evaluating motor evoked potentials (MEPs) elicited by cortical and subcortical stimulation of corticospinal axons and the activity in intracortical circuits in a finger muscle before and after 30 min of AIH or sham AIH. We found that the amplitude of cortically and subcortically elicited MEPs increased for 75 min after AIH but not sham AIH while intracortical activity remained unchanged. To examine further these subcortical effects, we assessed spike-timing dependent plasticity (STDP) targeting spinal synapses and the excitability of spinal motoneurons. Notably, AIH increased STDP outcomes while spinal motoneuron excitability remained unchanged. Our results provide the first evidence that AIH changes corticospinal function in humans, likely by altering corticospinal- motoneuronal synaptic transmission. AIH may represent a novel noninvasive approach for inducing spinal plasticity in humans.