Proteasome inhibitors suppress expression of NPM and ARF proteins
Proteasome inhibitors suppress expression of NPM and ARF proteins
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DOI：
10.4161/cc.10.22.18211
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发表时间：
2011-11-15
期刊：
影响因子：
4.3
通讯作者：
Gartel, Andrei L.
中科院分区：
文献类型：
--
作者：
Pandit, Bulbul;Gartel, Andrei L.
蛋白酶体抑制剂通过抑制蛋白质的降解来稳定多种蛋白质。之前我们已经证明蛋白酶体抑制剂硫链丝菌素、MG132 和硼替佐米矛盾地抑制 FOXM1 的转录活性和 mRNA/蛋白表达。在这里，我们证明，除了 FOXM1 之外，相同的蛋白酶体抑制剂也会降低 NPM 和 ARF 基因的 mRNA 和蛋白质表达。这些数据表明蛋白酶体抑制剂可能通过稳定其转录抑制剂来抑制基因表达。
Proteasome inhibitors stabilize numerous proteins by inhibiting their degradation. Previously we have demonstrated that proteasome inhibitors thiostrepton, MG132 and bortezomib paradoxically inhibit transcriptional activity and mRNA/protein expression of FOXM1. Here we demonstrate that, in addition to FOXM1, the same proteasome inhibitors also decrease mRNA and protein expression of NPM and ARF genes. These data suggest that proteasome inhibitors may suppress gene expression by stabilizing their transcriptional inhibitors.