The association between enteric viruses and necrotizing enterocolitis
The association between enteric viruses and necrotizing enterocolitis
复制标题
DOI：
10.1007/s00431-020-03746-w
复制
发表时间：
2020-07-22
影响因子：
3.6
通讯作者：
Yu, Jialin
中科院分区：
文献类型：
--
作者：
Cheng, Chen;He, Yu;Yu, Jialin
坏死性小肠结肠炎（NEC）的研究主要集中在肠道病毒。为探讨肠道病毒与NEC的关系，收集51例NEC患儿和39例正常新生儿粪便标本，检测轮状病毒（RV）、星状病毒（ASV）、痘病毒（Sapovirus）、肠道病毒（EV）、腺病毒（ADV）、EB病毒（EBV）、巨细胞病毒（CMV）和人博卡病毒（HBoV）。在NEC组和对照组中均检测到轮状病毒A（RVA）、ASV、EBV和ADV;然而，仅在NEC组中检测到EV和HBoV，两组均未检测到CMV。ASV是最常见的肠道病毒，但NEC和对照组之间没有显着差异，EBV和EV的情况类似。NEC组ADV和HBoV的患病率高于对照组（P = 0.011，P = 0.005），而RVA则相反（P = 0.014）。结论：不同病毒在NEC中的作用并不一致。一些，如ASV，可能被认为是新生儿的寄生虫，而在NEC患者中，ADV和EBV的存在可能与疾病的严重程度有关。已知：中心点NEC的病因仍然未知。关于坏死性小肠结肠炎（NEC）的研究主要集中在肠道病毒上，结论不一致。新的：中心点肠道病毒在新生儿肠道中很常见，但并不都是www. example. com dot ADV和EBV的存在可能与NEC的严重程度有关。
Studies on necrotizing enterocolitis (NEC) have not largely focused on enteric viruses. In order to demonstrate the association between enteric viruses and NEC, stool specimens of 51 neonates with NEC and 39 "normal" neonates were collected to detect rotavirus (RV), astrovirus (ASV), sapovirus, enterovirus (EV), adenovirus (ADV), Epstein-Barr virus (EBV), cytomegalovirus (CMV), and human bocavirus (HBoV). Rotavirus A (RVA), ASV, EBV, and ADV were detected in both the NEC and control groups; however, EV and HBoV were detected only in the NEC group and CMV was not detected in either group. ASV was the most common enteric virus, but no significant differences were found between NEC and control groups, as was similarly the case for EBV and EV. The prevalence of ADV and HBoV was higher in the NEC group than in the control group (P= 0.011,P= 0.005, respectively) but RVA showed the opposite trend (P= 0.014). Virus positivity or negativity had no influence on the clinical manifestation of NEC.Conclusion: The roles of different viruses in NEC are not congruent. Some, such as ASV, may be regarded as commensal in neonates, while in NEC patients, the presence of ADV and EBV may be related to severity of disease.What is known:center dot The etiology of NEC remains unknown. Studies on necrotizing enterocolitis (NEC) have not largely focused on enteric viruses and the conclusions were inconsistent.What is new:center dot Enteric viruses are common in the gut of neonates, but not all of them are pathogenic.center dot The existence of ADV and EBV may be related to the severity of NEC.