Effect of storage of red blood cells on alloimmunization
Effect of storage of red blood cells on alloimmunization
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DOI：
10.1111/trf.12156
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发表时间：
2013-11-01
期刊：
影响因子：
2.9
通讯作者：
Zwaginga, Jaap Jan
中科院分区：
文献类型：
--
作者：
Zalpuri, Saurabh;Schonewille, Henk;Zwaginga, Jaap Jan
红细胞（rbc）在储存过程中发生变化。各种研究表明，不良的风险更高，往往是多因素的临床结果与老年人储存的红细胞有关。因此，我们的目的是检查输血红细胞的储存是否也与红细胞特异性同种抗体形成的风险有关。研究设计和方法进行了一项双中心回顾性病例参照研究，病例患者和对照受试者从所有连续患者中取样，这些患者仅在两个中心中的一个接受了首次和随后的RBC输血。病例定义为首次出现红细胞同种抗体的患者。对照对象为未检测到红细胞同种抗体的患者，与病例患者红细胞输注次数相匹配。采用二元logistic回归分析检验红细胞保存时间与异体免疫发生的关系。结果144例患者和286例对照组接受了5478个红细胞。比较接受储存时间短于一定天数的单位与接受储存时间较长的单位（最长可达4周）的患者，没有发现同种异体免疫风险与储存时间类别之间的关联或趋势。结论输血红细胞保存时间1 ~ 4周不影响同种异体免疫风险。
BackgroundRed blood cells (RBCs) undergo changes during storage. Various studies have suggested a higher risk of adverse and often multifactorial clinical outcomes associated with older-stored RBCs. Our aim therefore was to examine if storage of transfused RBCs is also associated with the risk of RBC-specific alloantibody formation.Study Design and MethodsA two-center retrospective case-referent study was performed where case patients and control subjects were sampled from all consecutive patients who had received their first and subsequent RBC transfusions in one of the two centers only. Cases were defined as patients who developed a first RBC alloantibody. Control subjects were patients without detectable RBC alloantibodies, who were matched to the case patients regarding number of RBC transfusions. Binary logistic regression analysis was used to examine the association between storage time of RBCS and the occurrence of alloimmunization.ResultsA total of 144 cases and 286 controls were selected for our study, who had received a total 5478 RBC units. Comparing patients receiving units stored shorter than a certain number of days versus older units (with various storage periods up to 4 weeks) did not reveal an association or a trend between alloimmunization risk and storage time categories.ConclusionOur findings suggest that storage times of transfused RBCs between 1 and 4 weeks do not affect the risk of alloimmunization.