Coupling the Hemodynamic Environment to the Evolution of Cerebral Aneurysms: Computational Framework and Numerical Examples
Coupling the Hemodynamic Environment to the Evolution of Cerebral Aneurysms: Computational Framework and Numerical Examples
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DOI：
10.1115/1.3192141
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发表时间：
2009-10-01
影响因子：
1.7
通讯作者：
Ventikos, Yiannis
中科院分区：
文献类型：
--
作者：
Watton, Paul N.;Raberger, Nikolaus B.;Ventikos, Yiannis
引起脑动脉瘤发生和发展的生理机制被认为涉及作用于动脉壁的局部机械力与细胞水平上发生的生物过程之间的相互作用。事实上，作用于内皮细胞的壁面切应力（WSS）被认为起着关键作用。提出了一个计算框架，探讨脑动脉瘤的演变和血流动力学刺激的影响，作用于内皮细胞之间的联系。动脉瘤演变模型，利用动脉壁的现实微观结构模型，结合详细的3D血流动力学解决方案。发展中动脉瘤内血流的演变决定了作用于组织内皮细胞层的WSS和空间WSS梯度（WSSG）的分布。两个说明性的例子被认为是：降解的弹性蛋白成分是由WSS或WSSG从血压正常值的偏差。该模型为进一步探讨脑血管疾病的病因提供了基础。[DOI：10.1115/1.3192141]
The physiological mechanisms that give rise to the inception and development of a cerebral aneurysm are accepted to involve the interplay between the local mechanical forces acting on the arterial wall and the biological processes occurring at the cellular level. In fact, the wall shear stresses (WSSs) that act on the endothelial cells are thought to play a pivotal role. A computational framework is proposed to explore the link between the evolution of a cerebral aneurysm and the influence of hemodynamic stimuli that act on the endothelial cells. An aneurysm evolution model, which utilizes a realistic microstructural model of the arterial wall, is combined with detailed 3D hemodynamic solutions. The evolution of the blood flow within the developing aneurysm determines the distributions of the WSS and the spatial WSS gradient (WSSG) that act on the endothelial cell layer of the tissue. Two illustrative examples are considered: Degradation of the elastinous constituents is driven by deviations of WSS or the WSSG from normotensive values. This model provides the basis to further explore the etiology of aneurysmal disease. [DOI: 10.1115/1.3192141]