Bisindole alkaloids from Voacanga grandifolia leaves
Bisindole alkaloids from Voacanga grandifolia leaves
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DOI：
10.1007/s11418-020-01475-w
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发表时间：
2021-01-19
影响因子：
3.3
通讯作者：
Morita, Hiroshi
中科院分区：
文献类型：
--
作者：
Nugroho, Alfarius Eko;Ono, Yurika;Morita, Hiroshi
从大叶帽柱木（Voacanga grandifolia）的叶子中分离出两种新的双吲哚生物碱，12'-O-去甲基-沃布亭碱-5-内酰胺和异沃布亭碱-N-氧化物（1和2），以及两种已知的双吲哚生物碱。根据一维和二维核磁共振数据阐明了它们的结构。1和2对恶性疟原虫3D7显示出强大的抗疟活性，对人细胞系HepG2细胞的细胞毒活性非常低。[图表]
Two new bisindole alkaloids, 12 '-O-demethyl-vobtusine-5-lactam and isovobtusine-N-oxide (1 and 2), were isolated from the leaves of Voacanga grandifolia, together with two known bisindole alkaloids. Their structures were elucidated on the basis of 1D and 2D NMR data. 1 and 2 showed potent antimalarial activity against Plasmodium falciparum 3D7 and very low cytotoxic activity against a human cell line, HepG2 cells.[GRAPHICS].