Barriers to and facilitators of interventions to counter publication bias: thematic analysis of scholarly articles and stakeholder interviews.
Barriers to and facilitators of interventions to counter publication bias: thematic analysis of scholarly articles and stakeholder interviews.
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对抗出版偏见的干预措施的障碍和促进者：学术文章和利益相关者访谈的主题分析。
DOI：
10.1186/s12913-014-0551-z
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发表时间：
2014-11-13
影响因子：
2.8
通讯作者：
UNCOVER Project Consortium
中科院分区：
文献类型：
--
作者：
Kien C;Nußbaumer B;Thaler KJ;Griebler U;Van Noord MG;Wagner P;Gartlehner G;UNCOVER Project Consortium
当研究结果的性质和方向影响其发表的机会时，就会导致证据基础的扭曲--称为发表偏倚。尽管最近做出了相当大的努力来实施措施以减少不发表的试验，但发表偏倚仍然是医学研究中的一个主要问题。我们研究的目的是确定干预措施的障碍和促进因素，以防止或减少发表偏倚。我们系统地回顾了学术文献，并从文章中提取数据。此外，我们还与利益相关者进行了半结构化访谈。我们进行了归纳性的主题分析，以确定障碍和干预措施，以对抗出版偏见的促进者。系统性综述识别了39篇文章。在89名受邀的访谈伙伴中，有34名同意接受访谈。我们将干预措施分为四类：前瞻性试验注册，在同行评审期刊或研究报告中报告的激励措施，个人患者水平数据的公开可用性，以及同行评审/编辑过程。我们发现的障碍包括经济和个人利益，缺乏全球综合试验注册的财政资源，以及不同的法律的体系。确定的协调人包括：提高对发表偏倚影响的认识，提供激励措施以使数据可供临床使用，并实施法律以强制临床试验结果的前瞻性登记和报告。出版偏见是一个复杂的问题，反映了它发生的复杂系统。利益攸关方之间开展合作，提高公众对这一问题的认识，更好地制定鼓励出版的措施，并最终制定立法条例，这些都是减少出版偏见的最大潜力。本文的在线版本（doi：10.1186/s12913-014-0551-z）包含补充材料，可供授权用户使用。
When the nature and direction of research results affect their chances of publication, a distortion of the evidence base – termed publication bias – results. Despite considerable recent efforts to implement measures to reduce the non-publication of trials, publication bias is still a major problem in medical research. The objective of our study was to identify barriers to and facilitators of interventions to prevent or reduce publication bias. We systematically reviewed the scholarly literature and extracted data from articles. Further, we performed semi-structured interviews with stakeholders. We performed an inductive thematic analysis to identify barriers to and facilitators of interventions to counter publication bias. The systematic review identified 39 articles. Thirty-four of 89 invited interview partners agreed to be interviewed. We clustered interventions into four categories: prospective trial registration, incentives for reporting in peer-reviewed journals or research reports, public availability of individual patient-level data, and peer-review/editorial processes. Barriers we identified included economic and personal interests, lack of financial resources for a global comprehensive trial registry, and different legal systems. Facilitators identified included: raising awareness of the effects of publication bias, providing incentives to make data publically available, and implementing laws to enforce prospective registration and reporting of clinical trial results. Publication bias is a complex problem that reflects the complex system in which it occurs. The cooperation amongst stakeholders to increase public awareness of the problem, better tailoring of incentives to publish, and ultimately legislative regulations have the greatest potential for reducing publication bias. The online version of this article (doi:10.1186/s12913-014-0551-z) contains supplementary material, which is available to authorized users.
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影响因子：
--
作者：
Dubben, HH;Beck-Bornholdt, HP
通讯作者：
Beck-Bornholdt, HP
影响因子：
2.9
作者：
Abaid, Lisa N.;Grimes, David A.;Schulz, Kenneth F.
通讯作者：
Schulz, Kenneth F.
影响因子：
39.2
作者：
Bourgeois FT;Murthy S;Mandl KD
通讯作者：
Mandl KD
影响因子：
3.7
作者：
Dwan K;Gamble C;Williamson PR;Kirkham JJ;Reporting Bias Group
通讯作者：
Reporting Bias Group
影响因子：
8.8
作者：
Antonelli, Massimo;Mercurio, Giovanna
通讯作者：
Mercurio, Giovanna