Hypoandrogenism and abnormal regulation of gonadotropin secretion in rats fed a low protein diet.
Hypoandrogenism and abnormal regulation of gonadotropin secretion in rats fed a low protein diet.
复制标题
低蛋白饮食大鼠的雄激素水平低下和促性腺激素分泌异常调节。
DOI：
10.1210/endo-104-2-438
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发表时间：
1979
期刊：
影响因子：
4.8
通讯作者：
R. Swerdloff
中科院分区：
文献类型：
--
作者：
A. Glass;R. Mellitt;R. Vigersky;R. Swerdloff
对21日龄开始饲喂4周低蛋白饲料的大鼠下丘脑-垂体-睾丸轴的功能进行了评估。与对照组相比，低蛋白组精囊和前列腺重量减少，体外睾丸睾酮产量减少，尽管血清睾酮水平没有变化。尽管低蛋白组血清卵泡刺激素(基础和LHRH)低于对照组，但低蛋白组血清促黄体生成素(基础、LHRH和去势后)与对照组相比变化不一致。尽管基础FSH水平较低，但低蛋白组在去势后血清FSH水平高于正常水平。低蛋白组生精管直径和睾丸组织学正常，但睾丸雄激素结合蛋白缺失。在睾丸大小、睾丸组织学、雄激素排出量和血清FSH正常的适度限食对照组中，也检测不到睾丸雄激素结合蛋白。这一发现表明，睾丸雄激素结合蛋白的丢失可能是营养不良的敏感迹象。我们得出的结论是，尽管基础FSH低于正常水平，但喂食低蛋白饮食的大鼠雄激素水平低下，睾丸组织学正常，去势后FSH高于正常水平。后一种组合提示睾丸来源的促卵泡激素抑制物产生过多。
The function of the hypothalamic-pituitary-testicular axis was evaluated in rats fed a low protein diet for 4 weeks beginning at 21 days of age. Compared to control, the low protein group had decreased seminal vesicle and prostate weights as well as decreased testicular testosterone output in vitro, although serum testosterone was not different. The low protein group showed no consistent alterations in serum LH (basal, post-LHRH, and postcastration) compared to control although serum FSH (basal and post-LHRH) was lower in the low protein group. Despite this lower basal FSH, the low protein group had supranormal serum FSH after castration. Seminiferous tubule diameter and testicular histology were normal in the low protein group although testicular androgen-binding protein was absent. Testicular androgen-binding protein was also undetectable in a modestly food-restricted control group which had normal testicular size, testicular histology, androgen output, and serum FSH. This finding suggests that loss of testicular androgen-binding protein may be a sensitive sign of undernutrition. We conclude that rats fed a low protein diet have hypoandrogenism, normal testicular histology, and supranormal FSH after castration despite subnormal basal FSH. The latter combination suggests overproduction of an FSH inhibitor of testicular origin.