Efficient synthesis and evaluation of bimodal ligand NETA
Efficient synthesis and evaluation of bimodal ligand NETA
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DOI：
10.1016/j.bmcl.2008.03.084
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发表时间：
2008-06-01
影响因子：
2.7
通讯作者：
Ma, Xiang
中科院分区：
文献类型：
--
作者：
Chong, Hyun-Soon;Song, Hyun A.;Ma, Xiang
提出了一种结构新颖的双峰配体NETA的高效、短合成途径，用于肿瘤抗体靶向放射免疫治疗（RIT）。用x射线晶体学测定了NETA的结构。基于砷偶氮的紫外光谱络合动力学数据表明，NETA是一种很有前途的螯合剂，可用于（212）Bi, (213)Bi和（177）Lu的RIT应用。(c) 2008年Elsevier Ltd.出版
The efficient and short synthetic route to the structurally novel bimodal ligand NETA for antibody-targeted radiation therapy (radioimmunotherapy, RIT) of cancer was developed. The structure of NETA was determined by X-ray crystallography. The arsenazo-based UV spectroscopic complexation kinetics data suggest that NETA is a promising chelator for use in RIT applications of (212)Bi, (213)Bi, and (177)Lu. (c) 2008 Published by Elsevier Ltd.