Can bone tissue engineering contribute to therapy concepts after resection of musculoskeletal sarcoma?
Can bone tissue engineering contribute to therapy concepts after resection of musculoskeletal sarcoma?
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作者：
Holzapfel BM;Chhaya MP;Melchels FP;Holzapfel NP;Prodinger PM;von Eisenhart-Rothe R;van Griensven M;Schantz JT;Rudert M;Hutmacher DW
肌肉骨骼肉瘤的切除可导致大的骨缺损，其中需要再生的数量远远超过正常的自我愈合潜力。在许多情况下，由于辅助治疗方案、血清肿或感染，这些缺陷表现出有限的内在再生潜力。因此，这些缺损的重建仍然是骨科手术中要求最高的手术之一。常见治疗策略的限制引发了对新治疗概念的需求，以设计和设计无与伦比的结构和功能骨移植物。为了满足长期修复和良好临床结果的需要，需要从用惰性医疗器械替换组织的方法到专注于组织结构和功能的修复和重建的更多生物方法的范式转变。正是在这种背景下，骨组织工程领域可以提供解决方案，以实施骨和软组织肉瘤切除后的外科治疗概念。在本文中，我们将讨论组织工程的概念到骨科肿瘤学的临床领域的实施。
Resection of musculoskeletal sarcoma can result in large bone defects where regeneration is needed in a quantity far beyond the normal potential of self-healing. In many cases, these defects exhibit a limited intrinsic regenerative potential due to an adjuvant therapeutic regimen, seroma, or infection. Therefore, reconstruction of these defects is still one of the most demanding procedures in orthopaedic surgery. The constraints of common treatment strategies have triggered a need for new therapeutic concepts to design and engineer unparalleled structural and functioning bone grafts. To satisfy the need for long-term repair and good clinical outcome, a paradigm shift is needed from methods to replace tissues with inert medical devices to more biological approaches that focus on the repair and reconstruction of tissue structure and function. It is within this context that the field of bone tissue engineering can offer solutions to be implemented into surgical therapy concepts after resection of bone and soft tissue sarcoma. In this paper we will discuss the implementation of tissue engineering concepts into the clinical field of orthopaedic oncology.