Impact of changes in physical activity on health-related quality of life among patients with COPD
Impact of changes in physical activity on health-related quality of life among patients with COPD
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DOI：
10.1183/09031936.00021409
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发表时间：
2010-08-01
影响因子：
24.3
通讯作者：
Capelastegui, A.
中科院分区：
文献类型：
--
作者：
Esteban, C.;Quintana, J. M.;Capelastegui, A.
本研究的目的是评估定期体育活动（PA）的改变是否会影响慢性阻塞性肺疾病（COPD）患者的健康相关生活质量（HRQoL）。611例患者（平均年龄67.2+/-8.4岁，用力呼气量1 s 49.7+/-14.6）完成了圣乔治呼吸问卷（SGRQ）、慢性呼吸问卷（CRQ）和医疗结果简短表格（SF-36）问卷。PA被定义为患者自我报告的定期步行时间，分为低、中、高三种。5年后，391名幸存者再次完成了这些仪器。在对相关混杂因素进行调整后，基线时PA较低的患者和在研究期间PA升高的患者的SGRQ和CRQ评分分别提高了15.9分和8.7分。从中度到高PA的患者SGRQ评分提高了18.4分，CRQ评分提高了14.8分。在整个研究期间保持高水平PA的患者中观察到稍小的增加。在研究期间维持低水平的PA或降低PA与HRQoL的显著下降相关。在COPD患者中，减少使用PA的时间或维持低水平可能会损害HRQoL，而增加PA可以改善HRQoL参数。
The aim of this study was to evaluate whether changes in regular physical activity (PA) affect health-related quality of life (HRQoL) among patients with chronic obstructive pulmonary disease (COPD).611 patients (mean age 67.2+/-8.4 yrs; forced expiratory volume in 1 s 49.7+/-14.6) completed the St George's Respiratory Questionnaire (SGRQ), the Chronic Respiratory Questionnaire (CRQ) and the Medical Outcomes Short Form (SF-36) questionnaire. PA, defined as patients' self-reported regular walking times, was classified as low, moderate and high. After 5 yrs, 391 survivors completed these instruments again.After adjustment for relevant confounders, patients who reported low PA at baseline and who increased their PA over the study period improved their SGRQ and CRQ scores by 15.9 and 8.7 points, respectively. Patients who moved from moderate to high PA improved their SGRQ scores by 18.4 and their CRQ scores by 14.8. Slightly smaller increases were observed for patients who maintained a high level of PA throughout the study period. Maintaining a low level of PA or decreasing PA over the study period was associated with a significant HRQoL decline.Among COPD patients, a reduction in time spent engaging in PA or maintaining a low level may impair HRQoL, whereas an increase in PA can improve HRQoL parameters.