Competent stripes for diverse positions of limbs/fins in gnathostome embryos
Competent stripes for diverse positions of limbs/fins in gnathostome embryos
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DOI：
10.1111/j.1525-142x.2008.00288.x
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发表时间：
2008-10
影响因子：
2.9
通讯作者：
S. Yonei‐Tamura;Gembu Abe;Yoshio Tanaka;H. Anno;M. Noro;H. Ide;H. Aono;R. Kuraishi;N. Osumi;S. Kuratani;K. Tamura
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文献类型：
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作者：
S. Yonei‐Tamura;Gembu Abe;Yoshio Tanaka;H. Anno;M. Noro;H. Ide;H. Aono;R. Kuraishi;N. Osumi;S. Kuratani;K. Tamura
每种脊椎动物都有其独特的形态，以适应特定的生活方式和栖息地。四肢和鳍在大小、形状和沿着身体轴线的位置上惊人地多样化。这种形态上的多样性表明存在着多种胚胎发育程序。然而，各种胚胎的比较表明了肢体/鳍形成的共同机制。在这里，我们报告的存在连续条纹的能力，附件形成沿着背中线和侧干的所有主要有颌脊椎动物（gnathostome）组。我们还表明，软骨鱼的鳍芽发育共享的机制，前-后轴的形成，以及shh（音刺猬）的表达结构域在后芽。我们假设一个连续分布的主管条纹，代表共同的发展计划，在根的附属物形成有颚类。这种模式将允许随后的分歧，在每个动物组的四肢/鳍的不同水平。
SUMMARY Every vertebrate species has its own unique morphology adapted to a particular lifestyle and habitat. Limbs and fins are strikingly diversified in size, shape, and position along the body axis. This diversity in morphology suggests the existence of a variety of embryonic developmental programs. However, comparisons of various embryos suggest common mechanisms underlying limb/fin formation. Here, we report the existence of continuous stripes of competency for appendage formation along the dorsal midline and the lateral trunk of all of the major jawed vertebrate (gnathostome) groups. We also show that the developing fin buds of cartilaginous fish share a mechanism of anterior–posterior axis formation as well as an shh (sonic hedgehog) expression domain in the posterior bud. We hypothesize a continuous distribution of competent stripes that represents the common developmental program at the root of appendage formation in gnathostomes. This schema would have permitted subsequent divergence into various levels of limbs/fins in each animal group.