Ischemia in wound healing. II: Design of a flap model--biomechanical properties.
Ischemia in wound healing. II: Design of a flap model--biomechanical properties.
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伤口愈合时出现缺血。
DOI：
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发表时间：
1992
影响因子：
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通讯作者：
A. Viidik
中科院分区：
文献类型：
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作者：
A. Quirinia;A. Viidik
建立了一种标准化的可重复的H形双皮瓣模型，用于大鼠缺血性伤口的生物力学测试。愈合10天后，皮瓣伤口的所有生物力学参数显着下降，与正常愈合的切口伤口相比。愈合20天后，伸展性以及最重要的生物力学参数仍显着下降。在本研究的第一部分中，我们发现，在第1天，血流量下降到正常切口伤口血流量的7%，但在第16天恢复正常。在这里，我们表明，血流量的下降导致所有生物力学参数的显着降低，从而导致测试伤口愈合的显着延迟。生物力学参数与皮瓣表面坏死长度之间无相关性。因此，这些坏死不一定反映真皮的坏死，其中愈合负责皮肤的连续性和强度。
A standardized reproducible H-shaped double flap model for biomechanical testing of ischemic wounds was developed in rats. After 10 days of healing all the biomechanical parameters of the flap wounds decreased significantly, compared with normal healing incisional wounds. After 20 days of healing the extensibility as well as the most important biomechanical parameters were still significantly decreased. In part I of this study we showed that on day 1 the blood flow had decreased to 7% of the flow in normal incisional wounds, though it returned to normal on day 16. Here we show that this drop in blood flow results in a significant decrease in all the biomechanical parameters and thereby caused significant delay in the healing of the test wounds. There was no correlation between any of the biomechanical parameters and the length of surface necrosis on the flaps. These necroses thus do not necessarily reflect necrosis of the dermis, where the healing is responsible for the continuity and strength of the skin.