Successful treatment of post-stroke apathy by the dopamine receptor agonist ropinirole
Successful treatment of post-stroke apathy by the dopamine receptor agonist ropinirole
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DOI：
10.1016/j.jocn.2009.09.043
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发表时间：
2010-06-01
影响因子：
2
通讯作者：
Yamaguchi, Shuhei
中科院分区：
文献类型：
--
作者：
Kohno, Naoto;Abe, Satoshi;Yamaguchi, Shuhei
多巴胺D2/3受体激动剂已被广泛用于治疗帕金森病的运动症状，据报道还可改善认知和情绪障碍。在这里，我们描述了一位患者，他在前额叶皮质脑梗塞后出现了严重的冷漠。服用罗匹尼罗后，其言语输出和日常生活自发性均有明显改善。这种改善与前额叶皮质和基底节的血流增加有关。我们认为，罗匹尼罗可能是前额叶损伤后动机行为缺陷的一种治疗选择。(C)2009爱思唯尔有限公司。保留所有权利。
Dopamine D2/3 receptor agonists have been widely used to treat motor symptoms in Parkinson's disease and are also reported to improve cognitive and emotional disturbances. Here we describe a patient who developed severe apathy after cerebral infarction in the prefrontal cortex. After administration of ropinirole, his verbal output and spontaneity in daily life was improved remarkably. This improvement was associated with increased blood flow in the prefrontal cortex and basal ganglia. We suggest that ropinirole may be a treatment option for deficits in motivated behavior after prefrontal damage. (c) 2009 Elsevier Ltd. All rights reserved.