Circulating ceramides are inversely associated with cardiorespiratory fitness in participants aged 54-96 years from the Baltimore Longitudinal Study of Aging.
Circulating ceramides are inversely associated with cardiorespiratory fitness in participants aged 54-96 years from the Baltimore Longitudinal Study of Aging.
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DOI：
10.1111/acel.12491
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发表时间：
2016-10
期刊：
影响因子：
7.8
通讯作者：
Coen PM
中科院分区：
文献类型：
--
作者：
Fabbri E;Yang A;Simonsick EM;Chia CW;Zoli M;Haughey NJ;Mielke MM;Ferrucci L;Coen PM
心肺适合度(VO2峰值)随年龄增长而下降，是老年人发病率和死亡率的独立危险因素。识别低适合度的生物标志物可能会为一些人经历有氧能力加速下降的原因提供洞察，并可能作为心血管健康的临床有价值的预后指标。我们调查了参加巴尔的摩老龄化纵向研究(BLSA)的443名男性和女性(平均年龄69岁)循环神经酰胺与VO2峰值的关系。用高效液相色谱-串联质谱仪对神经酰胺的各个种类进行了定量。采用分级平板运动试验测定VO2峰值。我们应用多元回归模型来检验神经酰胺种类和VO2峰值之间的关系，同时调整了年龄、性别、血压、血清低密度脂蛋白、高密度脂蛋白、甘油三酯和其他协变量。我们发现，循环中C18：0、C20：0、C24：1神经酰胺和C20：0二氢神经酰胺水平较高与较低的有氧能力密切相关(P<0.001，P<0.001，P<0.018，P<0.001)。这些关联对两性都适用(男性比女性有更强的关联性，性行为互动的P值&0.05)，在调整混杂因素和多重比较校正后没有变化。有趣的是，没有发现与C16：0、C22：0、C24：0、C26：0和C22：1神经酰胺种类、C24：0二氢神经酰胺或总神经酰胺有显著关联。我们的分析显示，特定的长链神经酰胺与老年人心血管适合性低下密切相关，并可能与随年龄增长的适合性低下的发病机制有关。需要进行纵向研究，以进一步验证这些关联，并调查神经酰胺与健康结局之间的关系。
Cardiorespiratory fitness (VO 2 peak) declines with age and is an independent risk factor for morbidity and mortality in older adults. Identifying biomarkers of low fitness may provide insight for why some individuals experience an accelerated decline of aerobic capacity and may serve as clinically valuable prognostic indicators of cardiovascular health. We investigated the relationship between circulating ceramides and VO 2 peak in 443 men and women (mean age of 69) enrolled in the Baltimore Longitudinal Study of Aging (BLSA). Individual species of ceramide were quantified by HPLC–tandem mass spectrometry. VO 2 peak was measured by a graded treadmill test. We applied multiple regression models to test the associations between ceramide species and VO 2 peak, while adjusting for age, sex, blood pressure, serum LDL, HDL, triglycerides, and other covariates. We found that higher levels of circulating C18:0, C20:0, C24:1 ceramides and C20:0 dihydroceramides were strongly associated with lower aerobic capacity (P < 0.001, P < 0.001, P = 0.018, and P < 0.001, respectively). The associations held true for both sexes (with men having a stronger association than women, P value for sex interaction <0.05) and were unchanged after adjusting for confounders and multiple comparison correction. Interestingly, no significant association was found for C16:0, C22:0, C24:0, C26:0, and C22:1 ceramide species, C24:0 dihydroceramide, or total ceramides. Our analysis reveals that specific long‐chain ceramides strongly associate with low cardiovascular fitness in older adults and may be implicated in the pathogenesis of low fitness with aging. Longitudinal studies are needed to further validate these associations and investigate the relationship between ceramides and health outcomes.
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DOI：
10.1161/01.atv.20.12.2614
发表时间：
2000-12-01
影响因子：
8.7
作者：
Jiang, XC;Paultre, F;Tall, AR
通讯作者：
Tall, AR
影响因子：
8.2
作者：
Bergman, Bryan C.;Brozinick, Joseph T.;Perreault, Leigh
通讯作者：
Perreault, Leigh
影响因子：
7.8
作者：
Mielke, Michelle M.;Bandaru, Veera Venkata Ratnam;Haughey, Norman J.
通讯作者：
Haughey, Norman J.
影响因子：
37.8
作者：
Fleg, JL;Morrell, CH;Lakatta, EG
通讯作者：
Lakatta, EG
影响因子：
--
作者：
Hill, AV;Lupton, H
通讯作者：
Lupton, H