Hyperlipidemic Rabbit Models for Anti-Atherosclerotic Drug Development
Hyperlipidemic Rabbit Models for Anti-Atherosclerotic Drug Development
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DOI：
10.3390/app10238681
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发表时间：
2020-12
期刊：
影响因子：
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通讯作者：
M. Niimi;Yajie Chen;Haizhao Yan;Yao Wang;T. Koike;Jianglin Fan
中科院分区：
文献类型：
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作者：
M. Niimi;Yajie Chen;Haizhao Yan;Yao Wang;T. Koike;Jianglin Fan
高脂血症或血脂异常是动脉粥样硬化性疾病的主要危险因素。实验动物在阐明高脂血症病理生理的分子机制和药物开发方面发挥着重要作用。兔子是研究人类高脂血症最合适的模型之一，因为兔子的许多脂蛋白代谢特征与人类相似，如血浆中富含ldl的脂蛋白、载脂蛋白B mRNA编辑、胆固醇酯转移蛋白等。目前，研究高脂血症常用的兔模型有三种：(1)饮食性高脂血症兔，(2)自发性高脂血症兔，(3)基因操作兔（转基因和敲除兔）。本文就高脂血症家兔的特点作一综述，并讨论家兔在抗动脉粥样硬化药物开发中的应用价值。
Hyperlipidemia or dyslipidemia is a major risk factor for atherosclerotic diseases. Experimental animals play an important role in elucidating the molecular mechanisms of the pathophysiology of hyperlipidemia as well as in drug development. Rabbits are one of the most suitable models to study human hyperlipidemia because many features of the lipoprotein metabolism of rabbits are similar to those of humans such as LDL-rich lipoproteins in plasma, apolipoprotein B mRNA editing, and cholesteryl ester transfer protein. Currently, three types of rabbit models are commonly used for studying hyperlipidemia: (1) diet-induced hyperlipidemic rabbits, (2) spontaneous hyperlipidemic rabbits, and (3) gene-manipulated rabbits (transgenic and knockout rabbits). In this review, we give an overview of the features of hyperlipidemic rabbits and discuss the usefulness of rabbits for the development of anti-atherogenic drugs.