Glutathione peroxidase 4 (Gpx4) and ferroptosis: what's so special about it?
Glutathione peroxidase 4 (Gpx4) and ferroptosis: what's so special about it?
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DOI：
10.4161/23723556.2014.995047
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发表时间：
2015-07
影响因子：
2.1
通讯作者：
Friedmann Angeli JP
中科院分区：
文献类型：
--
作者：
Conrad M;Friedmann Angeli JP
系统XC - /谷胱甘肽/谷胱甘肽过氧化物酶4 （Gpx4）轴关键控制铁凋亡，一种最近被描述的调节的非凋亡细胞死亡形式。令人信服的证据表明，这种细胞死亡途径不仅与触发癌细胞死亡高度相关，而且还证明可用于治疗干预以阻止缺血/再灌注相关疾病。
The system XC−/glutathione/glutathione peroxidase 4 (Gpx4) axis pivotally controls ferroptosis, a recently described form of regulated non-apoptotic cell death. Compelling evidence has established that this route of cell death is not only of high relevance for triggering cancer cell death, but also proves to be amenable for therapeutic intervention to halt ischemia/reperfusion-related diseases.