Is there a hypercoagulable state in military fighter pilots?
Is there a hypercoagulable state in military fighter pilots?
复制标题
军用战斗机飞行员是否存在高凝状态？
DOI：
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发表时间：
1996
影响因子：
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通讯作者：
F. Marongiu
中科院分区：
文献类型：
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作者：
G. Biondi;S. Farrace;G. Mameli;F. Marongiu
背景
高凝状态与心血管疾病的发病率增加有关，心血管疾病是飞行人员永久停飞的最重要原因。
假设
我们研究的目的是调查喷气式飞机飞行员是否存在高凝状态，以及是否可能是由于飞行活动。
方法
为此，我们研究了10名喷气式飞机飞行员在标准化训练飞行使命后和对照组中的纤维蛋白肽A（FPA）、凝血酶-抗凝血酶复合物（达特）和D-二聚体（DD），这些是凝血和纤溶激活的敏感生化标志物。飞行前还对6名喷气式飞机飞行员进行了评估。
结果
与对照组相比，我们能够显示喷气式飞机飞行员的凝血酶和纤溶酶活性增加，并在飞行后对6名飞行员进行了两次评估。
结论
我们的结论是，高凝状态，由于飞行活动是目前在喷气式飞机飞行员飞行后。可能的机制涉及由飞行活动的神经内分泌反应介导的心理-生理应激的影响，或慢性+Gz暴露对心血管结构和功能的影响。
BACKGROUND
A hypercoagulable state is associated with an increased incidence of cardiovascular disease, the most important cause of permanent grounding of flying personnel.
HYPOTHESIS
The aim of our study was to investigate whether a hypercoagulable state is present in jet pilots, and whether it can be due to flight activity.
METHOD
To this purpose we studied Fibrinopeptide A (FPA), Thrombin-Antithrombin complexes (TAT) and D-Dimer (DD), sensitive biochemical markers of blood coagulation and fibrinolysis activation, in 10 jet pilots after a standardized training flight mission, and in a control group. Also evaluated before flight were 6 jet pilots.
RESULTS
We were able to show increased thrombin and plasmin activity both in jet pilots compared to the control group, and after flight in the 6 pilots who were evaluated twice.
CONCLUSION
We conclude that a hypercoagulable state due to flight activity is present in jet pilots after flight. Possible mechanisms involve an effect of psycho-physical stress mediated by a neuroendocrine response to flight activity, or an effect of chronic +Gz exposure on cardiovascular structure and function.