Regulation of Neural Stem Cell Competency and Commitment during Indirect Neurogenesis.
Regulation of Neural Stem Cell Competency and Commitment during Indirect Neurogenesis.
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DOI：
10.3390/ijms222312871
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发表时间：
2021-11-28
影响因子：
5.6
通讯作者：
Lee CY
中科院分区：
文献类型：
--
作者：
Rajan A;Ostgaard CM;Lee CY
间接神经发生，即神经干细胞通过中间祖细胞产生神经元，驱动无脑回脑的进化。尽管它们在间接神经发生中起作用，但指定中间祖细胞身份和调节干细胞能力以产生中间祖细胞的机制仍然知之甚少。良好的特点谱系层次和可用的强大的遗传工具，操纵基因功能，果蝇神经干细胞（神经母细胞）谱系一个很好的在体内的研究范式，调节神经发生的机制。蝇幼虫脑中的II型神经母细胞反复进行不对称分裂以产生中间神经祖细胞（INPs），所述中间神经祖细胞进行有限的增殖以增加每次干细胞分裂产生的神经元的数量。在这里，我们回顾了关键的调控基因和机制，他们促进规范和生成的INPs，保障间接生成的神经元在苍蝇幼虫脑神经发生。这些INPs调节因子的同源物已被证明在调节脊椎动物脑发育中发挥重要作用。对中间祖细胞的精确调控的深入了解可能会提高我们对大脑发育和大脑进化过程中间接神经发生控制的理解。
Indirect neurogenesis, during which neural stem cells generate neurons through intermediate progenitors, drives the evolution of lissencephalic brains to gyrencephalic brains. The mechanisms that specify intermediate progenitor identity and that regulate stem cell competency to generate intermediate progenitors remain poorly understood despite their roles in indirect neurogenesis. Well-characterized lineage hierarchy and available powerful genetic tools for manipulating gene functions make fruit fly neural stem cell (neuroblast) lineages an excellent in vivo paradigm for investigating the mechanisms that regulate neurogenesis. Type II neuroblasts in fly larval brains repeatedly undergo asymmetric divisions to generate intermediate neural progenitors (INPs) that undergo limited proliferation to increase the number of neurons generated per stem cell division. Here, we review key regulatory genes and the mechanisms by which they promote the specification and generation of INPs, safeguarding the indirect generation of neurons during fly larval brain neurogenesis. Homologs of these regulators of INPs have been shown to play important roles in regulating brain development in vertebrates. Insight into the precise regulation of intermediate progenitors will likely improve our understanding of the control of indirect neurogenesis during brain development and brain evolution.
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影响因子：
64.5
作者：
Homem, Catarina C. F.;Steinmann, Victoria;Knoblich, Juergen A.
通讯作者：
Knoblich, Juergen A.
影响因子：
56.9
作者：
Hirata, H;Yoshiura, S;Kageyama, R
通讯作者：
Kageyama, R
影响因子：
4.3
作者：
Borello, Ugo;Berarducci, Barbara;Dehay, Colette
通讯作者：
Dehay, Colette
DOI：
10.1242/dev.104497
发表时间：
2014-10
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Isomura A;Kageyama R
通讯作者：
Kageyama R
影响因子：
11.8
作者：
Bailey MJ;Prehoda KE
通讯作者：
Prehoda KE