Gastric B-cell mucosa-associated lymphoid tissue (MALT) lymphoma in an animal model of 'Helicobacter heilmannii' infection
Gastric B-cell mucosa-associated lymphoid tissue (MALT) lymphoma in an animal model of 'Helicobacter heilmannii' infection
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DOI：
10.1002/path.1593
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发表时间：
2004-08-01
影响因子：
7.3
通讯作者：
Lee, A
中科院分区：
文献类型：
--
作者：
O'Rourke, JL;Dixon, MF;Lee, A
虽然幽门螺杆菌被认为是人类胃部细菌的主要病原体，但一小部分人类感染与另一种微生物有关，通常被称为海尔曼氏螺杆菌，这种细菌在一系列动物物种中更为普遍。后一种细菌与各种人类胃病有关，包括胃炎、消化性溃疡和胃癌，包括胃B细胞粘膜相关淋巴组织(MALT)淋巴瘤。这项研究描述了在胃MALT淋巴瘤动物模型中对一些‘H Heilmannii’分离株的致病潜力的分析。用来自人类和动物宿主的10株不同的‘H heilmannii’分离株感染BALB/c小鼠。这些动物在感染后的不同时间点接受了长达28个月的检查。受感染的动物最初在6个月内出现慢性炎症反应。这种组织学反应的严重程度随着感染时间的延长和显性淋巴瘤的发展而增加。在一些动物感染18个月后。在高达25%的受感染动物中发现了MALT淋巴瘤。淋巴瘤的流行取决于感染的时间长短和感染菌株的来源。伴有淋巴细胞性浸润的其他组织学特征包括胃上皮及其伴生的增生性组织的内陷、粘液化生和少量弥漫性大B细胞淋巴瘤。在动物模型中经验地操纵细菌的存在的能力将允许进一步研究抗原驱动在幽门螺杆菌相关MALT淋巴瘤发展中的作用。版权所有(C)2004年大不列颠和爱尔兰病理学会。作者：John Wiley Sons，Ltd.
While Helicobacter pylori is accepted as the dominant human gastric bacterial pathogen, a small percentage of human infections have been associated with another organism, commonly referred to as 'Helicobacter heilmannii', which is more prevalent in a range of animal species. This latter bacterium has been seen in association with the full spectrum of human gastric diseases including gastritis, peptic ulceration, and gastric carcinomas, including gastric B-cell mucosa-associated lymphoid tissue (MALT) lymphoma. This study describes an analysis of the pathogenic potential of a number of 'H heilmannii' isolates in an animal model of gastric MALT lymphoma. BALB/c mice were infected with ten different 'H heilmannii' isolates originating from both human and animal hosts. The animals were examined at various time points for up to 28 months after infection. The infected animals initially developed a chronic inflammatory response within 6 months. This histological response increased in severity with the length of infection, with the development of overt lymphoma. in some animals 18 months after infection. MALT lymphomas were detected in up to 25% of the infected animals. The prevalence of lymphoma was dependent on the length of infection and the origin of the infecting isolates. A range of other histological features accompanied the lymphocytic infiltration, including invaginations of the gastric epithelium and associated hyperplastic tissue, mucus metaplasia, and a small number of diffuse large B-cell lymphomas. The ability to manipulate experientially the presence of the bacterium in the animal model will allow further studies examining the role of antigen drive in the development of Helicobacter-associated MALT lymphoma. Copyright (C) 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley Sons, Ltd.