Infantile papular acrodermatitis (Gianotti's disease) and intrafamilial occurence of acute hepatitis B with jaundice: age dependency of clinical manifestations of hepatitis B virus infection.
Infantile papular acrodermatitis (Gianotti's disease) and intrafamilial occurence of acute hepatitis B with jaundice: age dependency of clinical manifestations of hepatitis B virus infection.
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婴儿丘疹性肢端皮炎（贾诺蒂病）和家族内急性乙型肝炎伴黄疸的发生：乙型肝炎病毒感染临床表现的年龄依赖性。
DOI：
10.1093/infdis/138.2.211
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
T. Oda
中科院分区：
文献类型：
--
作者：
G. Toda;Y. Ishimaru;M. Mayumi;T. Oda
婴儿丘疹性肢端皮炎（IPA，Gianotti病）是儿童期B型肝炎病毒（HBV）感染的一种临床表现。1974年10月至1977年3月，日本松山发生了IPA流行病，在那里的一家儿科诊所有153名患者患有IPA。在此期间，12名母亲和两名父亲的患者感染急性B肝炎与明显的黄疸后3至14个月，他们的后代有IPA。对婴儿及其黄疸母亲和/或父亲的B型肝炎表面抗原（HBsAg）亚型分析表明，HBV是由婴儿传播的。尽管IPA患者的年龄从3个月到10岁不等，但所有索引病例都是1岁或更小。在大约40%的IPA患者中，年龄在1岁或1岁以下，HBs抗原血症持续1年。这些事实表明，IPA在儿童中的收缩，特别是那些一岁或以下，是建立HBV携带者状态的重要途径，维持这种病毒在社区中的水库。
Infantile papular acrodermatitis (IPA, Gianotti's disease) is a clinical manifestation of hepatitis B virus (HBV) infection in childhood. An epidemic of of IPA occurred in Matsuyama, Japan, where 153 patients in a pediatric clinic had IPA between October 1974 and March 1977. In this period 12 mothers and two fathers of patients contracted acute hepatitis B with overt jaundice three to 14 months after their offspring had IPA. Analysis of the subtype of hepatitis B surface antigen (HBsAg) in the infants and their jaundiced mothers and/or fathers disclosed that HBV was transmitted from the infants. All of the index cases were one year old or younger, although the age of patients with IPA ranged from three months to 10 years. In approximately 40% of patients with IPA who were one year old or younger, HBs antigenemia persisted for one year. These facts suggested that the contraction of IPA in children, especially those one year old or younger, was an important route toward establishment of the carrier state of HBV which maintains the reservoir of this virus in the community.