Dynamical Quorum Sensing and Synchronization in Large Populations of Chemical Oscillators
Dynamical Quorum Sensing and Synchronization in Large Populations of Chemical Oscillators
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DOI：
10.1126/science.1166253
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发表时间：
2009-01-30
期刊：
影响因子：
56.9
通讯作者：
Showalter, Kenneth
中科院分区：
文献类型：
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作者：
Taylor, Annette F.;Tinsley, Mark R.;Showalter, Kenneth
某些单细胞生物群体，例如营养液中的酵母悬浮液，随着细胞密度的增加而转变为协调活动。据信，集体行为是通过细胞外溶液的化学信号沟通而产生的。我们研究了具有明确动力学的大量异质离散化学振荡器（类似于 100,000 个），以表征两种不同类型的密度依赖转变到同步振荡行为。对于振荡器和周围溶液之间不同的化学交换率，增加振荡器密度导致（i）振荡活动逐渐同步，或（ii）同步振荡活动突然“开启”。我们通过相互作用的化学振荡器的数学模型分析了振荡器密度和信号物质交换率在这些转变中的作用。
Populations of certain unicellular organisms, such as suspensions of yeast in nutrient solutions, undergo transitions to coordinated activity with increasing cell density. The collective behavior is believed to arise through communication by chemical signaling via the extracellular solution. We studied large, heterogeneous populations of discrete chemical oscillators (similar to 100,000) with well- defined kinetics to characterize two different types of density- dependent transitions to synchronized oscillatory behavior. For different chemical exchange rates between the oscillators and the surrounding solution, increasing oscillator density led to ( i) the gradual synchronization of oscillatory activity, or ( ii) the sudden "switching on" of synchronized oscillatory activity. We analyze the roles of oscillator density and exchange rate of signaling species in these transitions with a mathematical model of the interacting chemical oscillators.