Treatment wish of individuals with known and unknown restless legs syndrome in the community
Treatment wish of individuals with known and unknown restless legs syndrome in the community
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DOI：
10.1007/s00415-008-0922-7
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发表时间：
2008-09-01
影响因子：
6
通讯作者：
Berger, Klaus
中科院分区：
文献类型：
--
作者：
Happe, Svenja;Vennemann, Mechthild;Berger, Klaus
不宁腿综合征（RLS）是一种常见的睡眠障碍，在高加索人群中患病率为5%至15%。多巴胺能治疗可以减轻感觉运动性睡眠倒睡症的症状，并被批准用于治疗睡眠倒睡症，但并非所有患者都要求治疗。约有2%至3%的患者就诊于初级保健医生，需要针对rls的治疗。然而，RLS患者的总体治疗偏好仍然未知。本研究的目的是在德国进行的一项基于人群的调查中，评估先前诊断和尚未诊断的RLS患者的患病率和治疗偏好。设计和设置多特蒙德健康研究中1312名参与者面对面访谈的横断面健康调查。根据国际不宁腿综合征研究组定义的RLS的四个最低诊断标准，对RLS进行标准化、有效的评估。参与者年龄在25至75岁之间，从城市登记册中随机选择。结果经医生诊断为RLS的患者总体患病率为2.3%。此外，6.5%满足四个最低标准，但不知道这个诊断，总患病率为8.8%。与男性（7.1%）和移民（6.7%）相比，女性（10.2%）和德国后裔（9.2%）的患病率更高。几乎60%的RLS病例每周至少出现一次症状。33.3%的已知RLS诊断病例和14.1%的未知诊断病例有RLS治疗愿望。后者取决于对诊断、日常症状、糖尿病和睡眠障碍的了解。结论约四分之一的RLS患者了解诊断，总体上每五分之一的RLS患者希望通过药物治疗有效减轻症状，占整个研究人群的1.6%。
Study objectives Restless legs syndrome (RLS) is a frequent sleep disorder with a prevalence of 5 % to 15 % in Caucasion populations. Dopaminergic treatment is known to reduce sensorimotor RLS symptoms and is approved for RLS, but not all patients ask for treatment. About 2 % to 3 % of patients presenting to a primary care physician require RLS-specific treatment. The overall treatment preference of RLS sufferers, however, is still unknown. The aim of this study was to assess the prevalence and treatment preference in patients with previously diagnosed and those with yet undiagnosed RLS in a population-based survey in Germany. Design and setting Cross-sectional health survey with face-to-face interviews with 1312 participants in the Dortmund Health Study. RLS was assessed with standardized, validated questions addressing the four minimal diagnostic criteria for RLS defined by the International Restless Legs Syndrome Study Group. Participants Participants were aged 25 to 75 years and were randomly selected from the city register. Results The overall prevalence of individuals with a known doctor diagnosis of RLS was 2.3 %. In addition, 6.5 % fulfilled the four minimal criteria but did not know about this diagnosis yielding an overall prevalence of 8.8 %. Prevalence was higher in women (10.2 %) and German descendents (9.2 %) compared to men (7.1 %) and migrants (6.7 %). Almost 60 % of all RLS cases reported symptoms at least once a week. 33.3 % of cases with a known RLS diagnosis and 14.1 % with an unknown diagnosis had an RLS treatment wish. The latter is determined by knowledge of the diagnosis, daily symptoms, diabetes and sleep disturbance. Conclusion About every fourth RLS case knows about the diagnosis and overall every fifth RLS case wishes medication to effectively reduce symptoms, corresponding to 1.6 % of the whole study population.