APPLICATION OF FRIEDEWALD LDL-CHOLESTEROL ESTIMATION FORMULA TO SERUM-LIPIDS IN THE JAPANESE POPULATION
APPLICATION OF FRIEDEWALD LDL-CHOLESTEROL ESTIMATION FORMULA TO SERUM-LIPIDS IN THE JAPANESE POPULATION
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DOI：
10.1253/jcj.50.1191
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发表时间：
1986-12-01
期刊：
影响因子：
--
通讯作者：
NAKAJIMA, K
中科院分区：
文献类型：
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作者：
HATA, Y;NAKAJIMA, K
当不能直接测量血清低密度脂蛋白胆固醇(LDL-c)时，可以用Friedewald提出的公式从总胆固醇(TC)、甘油三酯(TG)和高密度脂蛋白胆固醇(HDLc)中估算出它。[HDLc+Tg/k]，k=5。该公式假定极低密度脂蛋白中甘油三酯/胆固醇的比率为5：1。然而，它随血清甘油三酯水平的变化而变化，在甘油三酯低于400 mg/dl的日本人中平均为4。当k=4时，该公式更适合日本人，而不是原来的k=5时。此外，如果根据单个受试者的甘油三酯水平轮换k，得到更好的估计，即甘油三酯低于150 mg/dl的为3，甘油三酯为150-299 mg/dl的为4，甘油三酯为300-400 mg/dl的为5。当k=4时，估计的百分比误差小于5%，当使用变量k时，估计误差约为1%。
When direct measurement of serum low density lipoprotein cholesterol (LDL-c) is not available, it can be estimated from total cholesterol (TC), triglycerides (TG) and high density lipoprotein cholesterol (HDL-c) by using the formula proposed by Friedewald: LDL-c = TC.sbd.[HDL-c + TG/k], k = 5. This formula assumes the triglyceride/cholesterol ratio in VLDL to be 5:1. However, it is changeable with serum triglyceride levels, and averaged as 4 among Japanese with triglycerides less than 400 mg/dl. The formula provides a better fit for Japanese people, when k = 4, rather than original k = 5. In addition, a better estimation is gained, if k is rotated according to the triglyceride levels of individual subjects, i.e. 3 for those with triglycerides less than 150 mg/dl, 4 for those with triglycerides from 150 to 299 mg/dl, 5 for those with triglycerides from 300 to 400 mg/dl. The percent error of estimation is less than 5% when k = 4, and about 1% when variable k is employed for populations of about 1,000 subjects in number.