Endothelin potentiates growth factor-stimulated DNA synthesis in Swiss 3T3 cells.
Endothelin potentiates growth factor-stimulated DNA synthesis in Swiss 3T3 cells.
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DOI：
10.1111/j.1349-7006.1989.tb02310.x
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发表时间：
1989-04
期刊：
影响因子：
--
通讯作者：
Nakamura Y
中科院分区：
文献类型：
--
作者：
Kusuhara M;Yamaguchi K;Ohnishi A;Abe K;Kimura S;Oono H;Hori S;Nakamura Y
鼠细胞系Swiss 3T3通常用于细胞生长的研究。目前的研究表明，该细胞系具有内皮素的高亲和力受体，内皮素是一种来源于血管内皮细胞的血管活性肽。在该细胞系中，内皮素增强血小板衍生生长因子、碱性成纤维细胞生长因子或胰岛素刺激的DNA合成。在该细胞系中增强DNA合成所需的内皮素浓度几乎与先前在内皮素诱导的血管收缩中报道的相同。由于内皮素增加细胞内钙水平，该离子可能参与内皮素诱导DNA合成增强的信号转导途径。
A murine cell line, Swiss 3T3, is commonly used for the study of cellular growth. The present study revealed that this cell line possesses high‐affinity receptors for endothelin, a vasoactive peptide derived from vascular endothelial cells. In this cell line, endothelin potentiated DNA synthesis stimulated by platelet‐derived growth factor, basic fibroblast growth factor or insulin. The endothelin concentration required for potentiating DNA synthesis in this cell line is almost the same as that reported previously in endothelin‐induced vasoconstriction. Since endothelin increased intracellular calcium levels, this ion may participate in the signal transduction pathways by which endothelin induces potentiation of DNA synthesis.