Protein Tyrosine Phosphatases in Systemic Sclerosis: Potential Pathogenic Players and Therapeutic Targets.
Protein Tyrosine Phosphatases in Systemic Sclerosis: Potential Pathogenic Players and Therapeutic Targets.
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DOI：
10.1007/s11926-017-0655-7
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发表时间：
2017-05
影响因子：
5
通讯作者：
Bottini N
中科院分区：
文献类型：
--
作者：
Sacchetti C;Bottini N
The pathogenesis of systemic sclerosis depends on a complex interplay between autoimmunity, vasculopathy and fibrosis. Reversible phosphorylation on tyrosine residues in response to growth factors and other stimuli critically regulates each one of these key pathogenic processes. Protein tyrosine kinases, the enzymes that catalyze addition of phosphate to tyrosine residues, are known players in systemic sclerosis, and tyrosine kinases inhibitors are undergoing clinical trials for treatment of this disease. Protein tyrosine phosphatases, the enzymes that counteract the action of tyrosine kinases by removing phosphate from tyrosine residues, are emerging as important signaling mediators and molecular targets for cancer and other common diseases. However, until recently the role of tyrosine phosphatases in systemic sclerosis has remained largely unknown. Here we review the function of tyrosine phosphatases in pathways relevant to the pathogenesis of systemic sclerosis and their potential promise as therapeutic targets to halt progression of this debilitating rheumatic disease.
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影响因子：
6
作者：
Aschner, Yael;Khalifah, Anthony P.;Downey, Gregory P.
通讯作者：
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影响因子：
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影响因子：
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作者：
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通讯作者：
Varga, John
DOI：
10.1164/rccm.200307-957oc
发表时间：
2004-02-15
影响因子：
24.7
作者：
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通讯作者：
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影响因子：
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通讯作者：
Pozzi, Ambra