Aberrant crypt foci in patients with neoplastic and nonneoplastic colonic disease
Aberrant crypt foci in patients with neoplastic and nonneoplastic colonic disease
复制标题
DOI：
10.1016/s0046-8177(99)90302-7
复制
发表时间：
1999-01-01
期刊：
影响因子：
3.3
通讯作者：
Saraga, E
中科院分区：
文献类型：
--
作者：
Bouzourene, H;Chaubert, P;Saraga, E
Aberrant crypt foci (ACF) are putative preneoplastic lesions that might represent the earliest morphological lesion visible in colonic carcinogenesis. However, findings concerning the growth and morphological features of these lesions in human studies suggest that ACF are highly heterogeneous in nature. In this study, we evaluated the morphological features of a large number of ACF in colon mucosa of 26 patients with colorectal carcinoma (CRC), four patients with adenoma as well as seven patients with nonneoplastic colonic diseases. By dissecting microscope, 508 ACF were identified, and of these, 378 were sampled for histological examination. The median ACF density (number of ACF/cm(2)) was significantly higher in the left colon than in the right colon (0.047 v 0.014 ACF/cm(2)). Unexpectedly, in our series, the overall ACF density was higher in the nonneoplastic colonic diseases than in CRC (0.13 v 0.032 ACF/cm(2), P=.0087), cases of nonneoplastic diseases, however, being limited to 7 patients. ACF were significantly larger in colons with CRC or adenoma than in colons with nonneoplastic disease (P
