Neuropsychological differentiation of dementia with Lewy bodies from normal aging and Alzheimer's disease
Neuropsychological differentiation of dementia with Lewy bodies from normal aging and Alzheimer's disease
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DOI：
10.1080/13854040500376831
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发表时间：
2006-12-01
影响因子：
3.9
通讯作者：
Dickson, Dennis W.
中科院分区：
文献类型：
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作者：
Ferman, Tanis J.;Smith, Glenn E.;Dickson, Dennis W.
我们研究了选定的神经心理学措施在区分路易体痴呆（DLB）与正常衰老和阿尔茨海默病（AD）的诊断效用。从马约阿尔茨海默病患者登记处和阿尔茨海默病研究中心招募DLB患者（n = 87）、AD患者（n = 138）和一组正常对照（n = 103）。在以前的研究中显示有效用的神经心理学措施被纳入分析。区分DLB与正常对照的最终多变量逻辑回归模型包括听觉言语学习测试（AVLT）保留百分比、区组设计、连线测试-A部分和Benton视觉形式辨别。该模型的敏感性为88.6%，特异性为96.1%。区分DLB与AD的最终多变量逻辑模型包括Trail Making Part A、Boston Risk Test（BNT）、AVLT保留百分比和Rey-Osterrieth复杂图的副本。该模型的敏感性为83.3%，特异性为91.4%。AVLT和BNT具有负系数，表明较低的分数降低了DLB相对于AD的可能性。这些发现扩展了先前的研究，表明认知特征可以帮助DLB的临床诊断。早期注意力和视知觉障碍提示DLB，而早期记忆和命名障碍提示AD。
We examined the diagnostic utility of selected neuropsychological measures in the differentiation of dementia with Lewy bodies (DLB) from normal aging and Alzheimer's disease (AD). Patients with DLB (n = 87), AD (n = 138), and a group of normal controls (n = 103) were recruited from the Mayo Alzheimer's disease patient registry and Alzheimer's Disease Research Center. Neuropsychological measures shown to have utility in previous studies were included in the analysis. The final multivariate logistic regression model distinguishing DLB from normal controls included Auditory Verbal Learning Test (AVLT) percent retention, Block Design, Trail Making Test - Part A, and Benton Visual Form Discrimination. This model has a sensitivity of 88.6% and specificity of 96.1%. The final multivariate logistic model distinguishing DLB from AD included Trail Making Part A, Boston Naming Test (BNT), AVLT percent retention, and copy of the Rey-Osterrieth Complex Figure. This model had a sensitivity of 83.3% and a specificity of 91.4%. AVLT and BNT had negative coefficients, indicating that lower scores decreased the likelihood of DLB relative to AD. These finding extend prior research suggesting a cognitive profile that can aid in the clinical diagnosis of DLB. Early attention and visual perceptual disturbance suggests DLB, while early impairment in memory and naming suggests AD.